Automated description from the Alliance of Genome Resources
Exhibits protein homodimerization activity. Involved in several processes, including amyloid-beta metabolic process; engulfment of apoptotic cell; and negative regulation of cellular metabolic process. Localizes to several cellular components, including the autophagosome; phosphatidylinositol 3-kinase complex, class III; and trans-Golgi network. Predicted to colocalize with the mitochondrion. Used to study systemic lupus erythematosus. Human ortholog(s) of this gene implicated in Machado-Joseph disease. Is expressed in central nervous system; extraembryonic visceral endoderm; retina; and spleen. Orthologous to human BECN1 (beclin 1).