Automated description from the Alliance of Genome Resources (Release 3.2)
Contributes to endopeptidase activity. Involved in several processes, including amyloid precursor protein biosynthetic process; positive regulation of amyloid precursor protein biosynthetic process; and regulation of synaptic plasticity. Localizes to several cellular components, including Golgi apparatus; lysosome; and synaptic vesicle. Is expressed in several structures, including brain and genitourinary system. Used to study chronic myeloid leukemia; schizophrenia; and urinary bladder cancer. Human ortholog(s) of this gene implicated in Alzheimer's disease; hidradenitis suppurativa; and schizophrenia. Orthologous to human NCSTN (nicastrin).