Go Annotations as Summary Text (Tabular View) (GO Graph)

GO curators for mouse genes have assigned the following annotations to the gene product of Lgr4. (This text reflects annotations as of Wednesday, January 23, 2013.)

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Summary from NCBI RefSeq

[Summary is not available for the mouse gene. This summary is for the human ortholog.] G protein-coupled receptors (GPCRs) play key roles in a variety of physiologic functions. Members of the leucine-rich GPCR (LGR) family, such as GPR48, have multiple N-terminal leucine-rich repeats (LRRs) and a 7-transmembrane domain (Weng et al., 2008 [PubMed 18424556]).[supplied by OMIM, Aug 2008]

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Summary text based on GO annotations supported by experimental evidence in mouse

• Researchers have inferred, based on phenotypic analysis of mouse mutants, that the gene product of Lgr4
  • participates in the following biological processes:
    • canonical Wnt receptor signaling pathway involved in metanephric kidney development ^[2]
    • cell differentiation involved in metanephros development ^[2]
    • epithelial cell proliferation ^[1]
    • male genitalia development ^[1]
    • metanephric glomerulus development ^[2]
    • metanephric nephron tubule morphogenesis ^[2]
    • negative regulation of transcription, DNA-dependent ^[2]
    • positive regulation of branching involved in ureteric bud morphogenesis ^[2]
    • positive regulation of transcription, DNA-dependent ^[2]
    • tube morphogenesis ^[1]

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Summary text based on GO annotations supported by structural data

• Lgr4 encodes a protein or proteins that contain the following InterPro domains: Glycoprotein hormone receptor, GPCR, rhodopsin-like, GPCR, rhodopsin-like, 7TM, Leucine-rich repeat, Leucine-rich repeat, typical subtype, Leucine-rich repeat-containing N-terminal, indicating that the gene product:
  • participates in the following biological processes:
    • G-protein coupled receptor signaling pathway
  • performs the following molecular functions:
    • protein-hormone receptor activity
  • is located in the following cellular components:
    • integral to membrane

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Summary text for additional MGI annotations

• Automated translation to GO terms of SwissProt keywords that describe Lgr4 indicates that it:
  • participates in the following biological processes:
    • G-protein coupled receptor signaling pathway
    • signal transduction
  • performs the following molecular functions:
    • G-protein coupled receptor activity
    • signal transducer activity
  • is located in the following cellular components:
    • integral to membrane
    • membrane
    • plasma membrane

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References

1. Mendive F et al. (2006) Defective postnatal development of the male reproductive tract in LGR4 knockout mice. Dev Biol, 290:421-34. (PubMed:16406039)
2. Mohri Y et al. (2011) Lgr4-deficient mice showed premature differentiation of ureteric bud with reduced expression of Wnt effector Lef1 and Gata3. Dev Dyn, 240:1626-34. (PubMed:21523854)

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Gene Ontology Evidence Code Abbreviations:

EXP Inferred from experiment

IC Inferred by curator

IDA Inferred from direct assay

IEA Inferred from electronic annotation

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

ISS Inferred from sequence or structural similarity

ISO Inferred from sequence orthology

ISA Inferred from sequence alignment

ISM Inferred from sequence model

NAS Non-traceable author statement

ND No biological data available

RCA Reviewed computational analysis

TAS Traceable author statement

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