Automated description from the Alliance of Genome Resources (Release 3.1.1)
Exhibits several functions, including DNA-binding transcription factor activity, RNA polymerase II-specific; identical protein binding activity; and transcription corepressor activity. Involved in several processes, including positive regulation of T cell tolerance induction; regulation of cytokine production; and regulation of lymphocyte activation. Localizes to cytoplasm and nucleus. Is expressed in central nervous system; genitourinary system; hemolymphoid system; and retina. Used to study Wiskott-Aldrich syndrome and immune dysregulation-polyendocrinopathy-enteropathy-X-linked syndrome. Human ortholog(s) of this gene implicated in immune dysregulation-polyendocrinopathy-enteropathy-X-linked syndrome and type 1 diabetes mellitus. Orthologous to human FOXP3 (forkhead box P3).