Go Annotations as Summary Text (Tabular View) (GO Graph)

GO curators for mouse genes have assigned the following annotations to the gene product of Tbx19. (This text reflects annotations as of Wednesday, January 23, 2013.)

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Summary from NCBI RefSeq

[Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene is a member of a phylogenetically conserved family of genes that share a common DNA-binding domain, the T-box. T-box genes encode transcription factors involved in the regulation of developmental processes. Mutations in this gene were found in patients with isolated deficiency of pituitary POMC-derived ACTH, suggesting an essential role for this gene in differentiation of the pituitary POMC lineage. ACTH deficiency is characterized by adrenal insufficiency symptoms such as weight loss, lack of appetite (anorexia), weakness, nausea, vomiting, and low blood pressure. [provided by RefSeq, Jul 2008]

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Summary text based on GO annotations supported by experimental evidence in mouse

• Researchers have inferred from direct assay, that the gene product of Tbx19
  • participates in the following biological processes:
    • positive regulation of transcription from RNA polymerase II promoter ^[2]
    • regulation of transcription, DNA-dependent ^[3]
  • performs the following molecular functions:
    • DNA binding ^[3]
    • enhancer sequence-specific DNA binding ^[1]
    • sequence-specific DNA binding transcription factor activity ^[2]
• The gene product of Tbx19 has been shown to bind to the gene products of Nr5a1. ^[3]
• Researchers have inferred, based on phenotypic analysis of mouse mutants, that the gene product of Tbx19
  • participates in the following biological processes:
    • cell fate commitment ^[3]
    • pituitary gland development ^[2]
    • regulation of cell differentiation ^[1]
    • regulation of cell proliferation ^[2]
  • performs the following molecular functions:
    • DNA binding ^[2]
• Researchers have inferred, based on genetic interactions, that the gene product of Tbx19
  • participates in the following biological processes:
    • positive regulation of transcription from RNA polymerase II promoter based on interactions with Pou1f1 ^[2]

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Summary text based on GO annotations supported by structural data

• Tbx19 encodes a protein or proteins that contain the following InterPro domains: p53-like transcription factor, DNA-binding, Transcription factor, Brachyury, Transcription factor, T-box, Transcription factor, T-box, conserved site, indicating that the gene product:
  • is located in the following cellular components:
    • nucleus

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Summary text for additional MGI annotations

• Automated translation to GO terms of SwissProt keywords that describe Tbx19 indicates that it:
  • participates in the following biological processes:
    • transcription, DNA-dependent
  • is located in the following cellular components:
    • nucleus

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References

1. Budry L et al. (2012) The selector gene Pax7 dictates alternate pituitary cell fates through its pioneer action on chromatin remodeling. Genes Dev, 26:2299-310. (PubMed:23070814)
2. Liu J et al. (2001) Tbx19, a tissue-selective regulator of POMC gene expression. Proc Natl Acad Sci U S A, 98:8674-9. (PubMed:11447259)
3. Pulichino AM et al. (2003) Tpit determines alternate fates during pituitary cell differentiation. Genes Dev, 17:738-47. (PubMed:12651892)

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Gene Ontology Evidence Code Abbreviations:

EXP Inferred from experiment

IC Inferred by curator

IDA Inferred from direct assay

IEA Inferred from electronic annotation

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

ISS Inferred from sequence or structural similarity

ISO Inferred from sequence orthology

ISA Inferred from sequence alignment

ISM Inferred from sequence model

NAS Non-traceable author statement

ND No biological data available

RCA Reviewed computational analysis

TAS Traceable author statement

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