Automated description from the Alliance of Genome Resources
Exhibits actin filament binding activity. Involved in several processes, including bicellular tight junction assembly; positive regulation of pinocytosis; and protein localization to bicellular tight junction. Localizes to several cellular components, including the Z disc; cytoskeleton; and pseudopodium. Predicted to colocalize with the actin cytoskeleton. Used to study focal segmental glomerulosclerosis 1. Human ortholog(s) of this gene implicated in focal segmental glomerulosclerosis and focal segmental glomerulosclerosis 1. Is expressed in early conceptus and heart. Orthologous to human ACTN4 (actinin alpha 4).