Automated description from the Alliance of Genome Resources (Release 7.0.0)
Enables double-stranded DNA binding activity and metalloendopeptidase activity. Involved in nuclear envelope organization and protein maturation. Acts upstream of or within several processes, including heart development; regulation of intracellular signal transduction; and regulation of nucleobase-containing compound metabolic process. Located in membrane and nuclear envelope. Is expressed in early conceptus and oocyte. Used to study Emery-Dreifuss muscular dystrophy; familial partial lipodystrophy; and progeria. Human ortholog(s) of this gene implicated in mandibuloacral dysplasia type B lipodystrophy; restrictive dermopathy; and restrictive dermopathy 1. Orthologous to human ZMPSTE24 (zinc metallopeptidase STE24).