Go Annotations as Summary Text (Tabular View) (GO Graph)

GO curators for mouse genes have assigned the following annotations to the gene product of Paxip1. (This text reflects annotations as of Wednesday, January 23, 2013.)

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Summary from NCBI RefSeq

[Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene is a member of the paired box (PAX) gene family and encodes a nuclear protein with six BRCT (breast cancer carboxy-terminal) domains. This protein plays a critical role in maintaining genome stability, condensation of chromatin and progression through mitosis. [provided by RefSeq, Jul 2008]

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Summary text based on GO annotations supported by experimental evidence in mouse

• Researchers have inferred from direct assay, that the gene product of Paxip1
  • participates in the following biological processes:
    • response to DNA damage stimulus ^[1]
  • is located in the following cellular components:
    • histone methyltransferase complex ^[1]
    • nucleus ^{[1, 3, 6]}
• The gene product of Paxip1 has been shown to bind to the gene products of Pax2. ^{[5, 6]}
• Researchers have inferred, based on phenotypic analysis of mouse mutants, that the gene product of Paxip1
  • participates in the following biological processes:
    • adipose tissue development ^[2]
    • chorion development ^[7]
    • endothelial cell migration ^[7]
    • positive regulation of histone acetylation ^[3]
    • positive regulation of histone H3-K36 methylation ^[3]
    • positive regulation of histone H3-K4 methylation ^{[2, 3]}
    • positive regulation of isotype switching ^[3]
    • positive regulation of protein ubiquitination ^[4]
    • positive regulation of transcription initiation from RNA polymerase II promoter ^{[2, 3]}
    • vasculogenesis ^[7]

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Summary text based on GO annotations supported by experimental evidence in other organisms

• From comparative sequence analysis (see table for details), MGI curators have determined that the gene product of Paxip1:
  • participates in the following biological processes:
    • DNA damage response, signal transduction by p53 class mediator
    • histone H3-K4 methylation
    • positive regulation of transcription initiation from RNA polymerase II promoter
    • response to ionizing radiation
  • is located in the following cellular components:
    • histone methyltransferase complex
    • nucleus

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Summary text for additional MGI annotations

• Automated translation to GO terms of SwissProt keywords that describe Paxip1 indicates that it:
  • participates in the following biological processes:
    • DNA recombination
    • DNA repair
    • regulation of transcription, DNA-dependent
    • transcription, DNA-dependent

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References

1. Cho YW et al. (2007) PTIP associates with MLL3- and MLL4-containing histone H3 lysine 4 methyltransferase complex. J Biol Chem, 282:20395-406. (PubMed:17500065)
2. Cho YW et al. (2009) Histone methylation regulator PTIP is required for PPARgamma and C/EBPalpha expression and adipogenesis. Cell Metab, 10:27-39. (PubMed:19583951)
3. Daniel JA et al. (2010) PTIP promotes chromatin changes critical for immunoglobulin class switch recombination. Science, 329:917-23. (PubMed:20671152)
4. Gohler T et al. (2008) PTIP/Swift is required for efficient PCNA ubiquitination in response to DNA damage. DNA Repair (Amst), 7:775-87. (PubMed:18353733)
5. Gong Z et al. (2009) Accumulation of Pax2 transactivation domain interaction protein (PTIP) at sites of DNA breaks via RNF8-dependent pathway is required for cell survival after DNA damage. J Biol Chem, 284:7284-93. (PubMed:19124460)
6. Lechner MS et al. (2000) PTIP, a novel BRCT domain-containing protein interacts with Pax2 and is associated with active chromatin. Nucleic Acids Res, 28:2741-51. (PubMed:10908331)
7. Mu W et al. (2008) An allelic series uncovers novel roles of the BRCT domain-containing protein PTIP in mouse embryonic vascular development. Mol Cell Biol, 28:6439-51. (PubMed:18710940)

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Gene Ontology Evidence Code Abbreviations:

EXP Inferred from experiment

IC Inferred by curator

IDA Inferred from direct assay

IEA Inferred from electronic annotation

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

ISS Inferred from sequence or structural similarity

ISO Inferred from sequence orthology

ISA Inferred from sequence alignment

ISM Inferred from sequence model

NAS Non-traceable author statement

ND No biological data available

RCA Reviewed computational analysis

TAS Traceable author statement

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