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Gene Ontology Classifications
PAX interacting (with transcription-activation domain) protein 1

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GO curators for mouse genes have assigned the following annotations to the gene product of Paxip1. (This text reflects annotations as of Tuesday, May 26, 2015.)
Summary from NCBI RefSeq

This gene encodes a nuclear-localized protein that contains six BRCT1 (C-terminal of breast cancer susceptibility protein) domains. The encoded protein is involved in the repair of DNA double-strand breaks and is necessary for progression through cell division. The protein also functions in the regulation of transcription by recruiting histone methyltransferases to gene promoters bound by the sequence-specific transcription factor paired box protein 2 (Pax2). [provided by RefSeq, Mar 2013]
Summary text based on GO annotations supported by experimental evidence in mouse
Summary text for additional MGI annotations
  1. Cho YW et al. (2007) PTIP associates with MLL3- and MLL4-containing histone H3 lysine 4 methyltransferase complex. J Biol Chem, 282:20395-406. (PubMed:17500065)
  2. Cho YW et al. (2009) Histone methylation regulator PTIP is required for PPARgamma and C/EBPalpha expression and adipogenesis. Cell Metab, 10:27-39. (PubMed:19583951)
  3. Daniel JA et al. (2010) PTIP promotes chromatin changes critical for immunoglobulin class switch recombination. Science, 329:917-23. (PubMed:20671152)
  4. Gohler T et al. (2008) PTIP/Swift is required for efficient PCNA ubiquitination in response to DNA damage. DNA Repair (Amst), 7:775-87. (PubMed:18353733)
  5. Gong Z et al. (2009) Accumulation of Pax2 transactivation domain interaction protein (PTIP) at sites of DNA breaks via RNF8-dependent pathway is required for cell survival after DNA damage. J Biol Chem, 284:7284-93. (PubMed:19124460)
  6. Lechner MS et al. (2000) PTIP, a novel BRCT domain-containing protein interacts with Pax2 and is associated with active chromatin. Nucleic Acids Res, 28:2741-51. (PubMed:10908331)
  7. McManus S et al. (2011) The transcription factor Pax5 regulates its target genes by recruiting chromatin-modifying proteins in committed B cells. EMBO J, 30:2388-404. (PubMed:21552207)
  8. Mu W et al. (2008) An allelic series uncovers novel roles of the BRCT domain-containing protein PTIP in mouse embryonic vascular development. Mol Cell Biol, 28:6439-51. (PubMed:18710940)

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Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment
  IAS Inferred from ancestral sequence
  IBA Inferred from biological aspect of ancestor
  IBD Inferred from biological aspect of descendant
  IC Inferred by curator
  IDA Inferred from direct assay
  IEA Inferred from electronic annotation
  IGI Inferred from genetic interaction
  IKR Inferred from key residues
  IMP Inferred from mutant phenotype
  IMR Inferred from missing residues
  IPI Inferred from physical interaction
  IRD Inferred from rapid divergence
  ISS Inferred from sequence or structural similarity
  ISO Inferred from sequence orthology
  ISA Inferred from sequence alignment
  ISM Inferred from sequence model
  NAS Non-traceable author statement
  ND No biological data available
  RCA Reviewed computational analysis
  TAS Traceable author statement


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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MGI 6.0
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