Go Annotations as Summary Text (Tabular View) (GO Graph)

GO curators for mouse genes have assigned the following annotations to the gene product of Igf2bp2. (This text reflects annotations as of Wednesday, January 23, 2013.)

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Summary from NCBI RefSeq

[Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a member of the IGF-II mRNA-binding protein (IMP) family. The protein encoded by this gene contains several four KH domains and two RRM domains. It functions by binding to the 5' UTR of the insulin-like growth factor 2 (IGF2) mRNA and regulating IGF2 translation. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008]

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Summary text based on GO annotations supported by experimental evidence in other organisms

• From comparative sequence analysis (see table for details), MGI curators have determined that the gene product of Igf2bp2:
  • performs the following molecular functions:
    • mRNA 3'-UTR binding
    • mRNA 5'-UTR binding
  • is located in the following cellular components:
    • cytoplasm
    • cytoskeletal part
    • nucleus

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Summary text based on GO annotations supported by structural data

• Igf2bp2 encodes a protein or proteins that contain the following InterPro domains: K Homology domain, K Homology domain, type 1, Nucleotide-binding, alpha-beta plait, RNA recognition motif domain, indicating that the gene product:
  • performs the following molecular functions:
    • nucleic acid binding
    • nucleotide binding
    • RNA binding

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Summary text for additional MGI annotations

• Automated translation to GO terms of SwissProt keywords that describe Igf2bp2 indicates that it:
  • participates in the following biological processes:
    • regulation of translation
  • performs the following molecular functions:
    • RNA binding

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Gene Ontology Evidence Code Abbreviations:

EXP Inferred from experiment

IC Inferred by curator

IDA Inferred from direct assay

IEA Inferred from electronic annotation

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

ISS Inferred from sequence or structural similarity

ISO Inferred from sequence orthology

ISA Inferred from sequence alignment

ISM Inferred from sequence model

NAS Non-traceable author statement

ND No biological data available

RCA Reviewed computational analysis

TAS Traceable author statement

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