Go Annotations as Summary Text (Tabular View) (GO Graph)

GO curators for mouse genes have assigned the following annotations to the gene product of Igf2bp1. (This text reflects annotations as of Wednesday, January 23, 2013.)

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Summary from NCBI RefSeq

[Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a member of the insulin-like growth factor 2 mRNA-binding protein family. The protein encoded by this gene contains four K homology domains and two RNA recognition motifs. It functions by binding to the mRNAs of certain genes, including insulin-like growth factor 2, beta-actin and beta-transducin repeat-containing protein, and regulating their translation. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2009]

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Summary text based on GO annotations supported by experimental evidence in other organisms

• From comparative sequence analysis (see table for details), MGI curators have determined that the gene product of Igf2bp1:
  • participates in the following biological processes:
    • CRD-mediated mRNA stabilization
    • negative regulation of translation
    • regulation of mRNA stability involved in response to stress
    • RNA localization
  • performs the following molecular functions:
    • mRNA 3'-UTR binding
    • mRNA 5'-UTR binding
    • mRNA binding
    • translation regulator activity
  • is located in the following cellular components:
    • CRD-mediated mRNA stability complex
    • cytoplasm
    • cytoplasmic stress granule
    • dendrite
    • intracellular membrane-bounded organelle
    • nucleus
    • plasma membrane
    • ribonucleoprotein complex

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Summary text based on GO annotations supported by structural data

• Igf2bp1 encodes a protein or proteins that contain the following InterPro domains: K Homology domain, K Homology domain, type 1, Nucleotide-binding, alpha-beta plait, RNA recognition motif domain, indicating that the gene product:
  • performs the following molecular functions:
    • nucleic acid binding
    • nucleotide binding
    • RNA binding

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Summary text for additional MGI annotations

• Automated translation to GO terms of SwissProt keywords that describe Igf2bp1 indicates that it:
  • participates in the following biological processes:
    • regulation of translation
  • performs the following molecular functions:
    • RNA binding

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Gene Ontology Evidence Code Abbreviations:

EXP Inferred from experiment

IC Inferred by curator

IDA Inferred from direct assay

IEA Inferred from electronic annotation

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

ISS Inferred from sequence or structural similarity

ISO Inferred from sequence orthology

ISA Inferred from sequence alignment

ISM Inferred from sequence model

NAS Non-traceable author statement

ND No biological data available

RCA Reviewed computational analysis

TAS Traceable author statement

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