Automated description from the Alliance of Genome Resources
Exhibits several functions, including DNA-binding transcription repressor activity, RNA polymerase II-specific; RNA polymerase II transcription factor binding activity; and transcription regulatory region sequence-specific DNA binding activity. Involved in several processes, including limb morphogenesis; nephron morphogenesis; and nervous system development. Localizes to the NuRD complex and heterochromatin. Used to study Townes-Brocks syndrome. Human ortholog(s) of this gene implicated in Townes-Brocks syndrome and middle lobe syndrome. Is expressed in several structures, including branchial arch; central nervous system; limb; metanephros; and sensory organ. Orthologous to human SALL1 (spalt like transcription factor 1).