Automated description from the Alliance of Genome Resources (Release 3.2)
Exhibits several functions, including DNA-binding transcription repressor activity, RNA polymerase II-specific; RNA polymerase II cis-regulatory region sequence-specific DNA binding activity; and RNA polymerase II transcription factor binding activity. Involved in several processes, including limb morphogenesis; nephron morphogenesis; and nervous system development. Localizes to NuRD complex and heterochromatin. Is expressed in several structures, including branchial arch; central nervous system; limb; metanephros; and sensory organ. Used to study Townes-Brocks syndrome. Human ortholog(s) of this gene implicated in Townes-Brocks syndrome and middle lobe syndrome. Orthologous to human SALL1 (spalt like transcription factor 1).