Go Annotations as Summary Text (Tabular View) (GO Graph)

GO curators for mouse genes have assigned the following annotations to the gene product of Adar. (This text reflects annotations as of Wednesday, January 23, 2013.)

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Summary from NCBI RefSeq

[Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes the enzyme responsible for RNA editing by site-specific deamination of adenosines. This enzyme destabilizes double-stranded RNA through conversion of adenosine to inosine. Mutations in this gene have been associated with dyschromatosis symmetrica hereditaria. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2010]

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Summary text based on GO annotations supported by experimental evidence in mouse

• Researchers have inferred from direct assay, that the gene product of Adar
  • participates in the following biological processes:
    • adenosine to inosine editing ^[3]
  • is located in the following cellular components:
    • cytoplasm ^[4]
    • nucleolus ^[4]
    • nucleus ^[4]
• The gene product of Adar has been shown to bind to the gene products of Eif2ak2, Wdhd1. ^{[1, 2]}
• Researchers have inferred, based on phenotypic analysis of mouse mutants, that the gene product of Adar
  • participates in the following biological processes:
    • negative regulation of apoptotic process ^[4]
    • negative regulation of protein kinase activity by regulation of protein phosphorylation ^[1]
    • positive regulation of viral genome replication ^[1]

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Summary text based on GO annotations supported by experimental evidence in other organisms

• From comparative sequence analysis (see table for details), MGI curators have determined that the gene product of Adar:
  • participates in the following biological processes:
    • adenosine to inosine editing
    • base conversion or substitution editing
    • negative regulation of protein kinase activity by regulation of protein phosphorylation
    • positive regulation of viral genome replication
    • protein export from nucleus
    • protein import into nucleus
    • response to interferon-alpha
    • response to virus
  • performs the following molecular functions:
    • double-stranded RNA adenosine deaminase activity
    • double-stranded RNA binding
  • is located in the following cellular components:
    • cytoplasm
    • nucleus
    • supraspliceosomal complex

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Summary text based on GO annotations supported by structural data

• Adar encodes a protein or proteins that contain the following InterPro domains: Adenosine deaminase/editase, Double-stranded RNA-binding, Double-stranded RNA-binding-like, Double-stranded RNA-specific adenosine deaminase (DRADA), Winged helix-turn-helix transcription repressor DNA-binding, indicating that the gene product:
  • participates in the following biological processes:
    • RNA processing
  • performs the following molecular functions:
    • adenosine deaminase activity
    • RNA binding
  • is located in the following cellular components:
    • intracellular

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Summary text for additional MGI annotations

• Automated translation to GO terms of SwissProt keywords that describe Adar indicates that it:
  • participates in the following biological processes:
    • gene silencing by RNA
    • mRNA processing
    • regulation of transcription, DNA-dependent
    • transcription, DNA-dependent
  • performs the following molecular functions:
    • DNA binding
    • hydrolase activity
    • metal ion binding
    • RNA binding

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References

1. Agranat L et al. (2008) The editing enzyme ADAR1 and the mRNA surveillance protein hUpf1 interact in the cell nucleus. Proc Natl Acad Sci U S A, 105:5028-33. (PubMed:18362360)
2. Hsieh CL et al. (2011) WDHD1 modulates the post-transcriptional step of the centromeric silencing pathway. Nucleic Acids Res, 39:4048-62. (PubMed:21266480)
3. Ohlson J et al. (2007) Editing modifies the GABA(A) receptor subunit alpha3. RNA, 13:698-703. (PubMed:17369310)
4. Wang Q et al. (2004) Stress-induced apoptosis associated with null mutation of ADAR1 RNA editing deaminase gene. J Biol Chem, 279:4952-61. (PubMed:14613934)

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Gene Ontology Evidence Code Abbreviations:

EXP Inferred from experiment

IC Inferred by curator

IDA Inferred from direct assay

IEA Inferred from electronic annotation

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

ISS Inferred from sequence or structural similarity

ISO Inferred from sequence orthology

ISA Inferred from sequence alignment

ISM Inferred from sequence model

NAS Non-traceable author statement

ND No biological data available

RCA Reviewed computational analysis

TAS Traceable author statement

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