Go Annotations as Summary Text (Tabular View) (GO Graph)

GO curators for mouse genes have assigned the following annotations to the gene product of Ap1s2. (This text reflects annotations as of Wednesday, January 23, 2013.) MGI curation of this mouse gene is considered complete, including annotations derived from the biomedical literature as of February 9, 2010. If you know of any additional information regarding this mouse gene please let us know. Please supply mouse gene symbol and a PubMed ID.

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Summary from NCBI RefSeq

[Summary is not available for the mouse gene. This summary is for the human ortholog.] Adaptor protein complex 1 is found at the cytoplasmic face of coated vesicles located at the Golgi complex, where it mediates both the recruitment of clathrin to the membrane and the recognition of sorting signals within the cytosolic tails of transmembrane receptors. This complex is a heterotetramer composed of two large, one medium, and one small adaptin subunit. The protein encoded by this gene serves as the small subunit of this complex and is a member of the adaptin protein family. Transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2013]

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Summary text based on GO annotations supported by structural data

• Ap1s2 encodes a protein or proteins that contain the following InterPro domains: Adaptor protein complex, sigma subunit, AP complex, mu/sigma subunit, Clathrin adaptor complex, small chain, Longin-like domain, indicating that the gene product:
  • participates in the following biological processes:
    • intracellular protein transport
    • protein transport
    • transport
    • vesicle-mediated transport
  • performs the following molecular functions:
    • protein transporter activity
  • is located in the following cellular components:
    • membrane coat

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Summary text for additional MGI annotations

• Automated translation to GO terms of SwissProt keywords that describe Ap1s2 indicates that it:
  • participates in the following biological processes:
    • endocytosis
    • protein transport
    • transport
  • is located in the following cellular components:
    • coated pit
    • cytoplasmic vesicle
    • Golgi apparatus
    • membrane
• Annotations directly to for the gene Ap1s2 indicate that MGI curators have found no experimental data [literature] to support further annotation to these categories at this time.

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Gene Ontology Evidence Code Abbreviations:

EXP Inferred from experiment

IC Inferred by curator

IDA Inferred from direct assay

IEA Inferred from electronic annotation

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

ISS Inferred from sequence or structural similarity

ISO Inferred from sequence orthology

ISA Inferred from sequence alignment

ISM Inferred from sequence model

NAS Non-traceable author statement

ND No biological data available

RCA Reviewed computational analysis

TAS Traceable author statement

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