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Gene Ontology Classifications
Symbol
Name
ID
Tbx21
T-box 21
MGI:1888984

Go Annotations as Summary Text (Tabular View) (GO Graph)

GO curators for mouse genes have assigned the following annotations to the gene product of Tbx21. (This text reflects annotations as of Thursday, July 24, 2014.)
Summary from NCBI RefSeq


[Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene is a member of a phylogenetically conserved family of genes that share a common DNA-binding domain, the T-box. T-box genes encode transcription factors involved in the regulation of developmental processes. This gene is the human ortholog of mouse Tbx21/Tbet gene. Studies in mouse show that Tbx21 protein is a Th1 cell-specific transcription factor that controls the expression of the hallmark Th1 cytokine, interferon-gamma (IFNG). Expression of the human ortholog also correlates with IFNG expression in Th1 and natural killer cells, suggesting a role for this gene in initiating Th1 lineage development from naive Th precursor cells. [provided by RefSeq, Jul 2008]
Summary text based on GO annotations supported by experimental evidence in mouse
Summary text based on GO annotations supported by experimental evidence in other organisms
Summary text based on GO annotations supported by structural data
Summary text for additional MGI annotations
References
  1. Enomoto T et al. (2011) Bcl11b/Ctip2 Controls the Differentiation of Vomeronasal Sensory Neurons in Mice. J Neurosci, 31:10159-10173. (PubMed:21752992)
  2. Gerth AJ et al. (2003) T-bet regulates T-independent IgG2a class switching. Int Immunol, 15:937-44. (PubMed:12882831)
  3. Jenner RG et al. (2009) The transcription factors T-bet and GATA-3 control alternative pathways of T-cell differentiation through a shared set of target genes. Proc Natl Acad Sci U S A, 106:17876-81. (PubMed:19805038)
  4. Lazarevic V et al. (2011) T-bet represses T(H)17 differentiation by preventing Runx1-mediated activation of the gene encoding RORgammat. Nat Immunol, 12:96-104. (PubMed:21151104)
  5. Oestreich KJ et al. (2012) Molecular mechanisms that control the expression and activity of Bcl-6 in TH1 cells to regulate flexibility with a TFH-like gene profile. Nat Immunol, 13:405-11. (PubMed:22406686)
  6. Turchinovich G et al. (2011) Skint-1 Identifies a Common Molecular Mechanism for the Development of Interferon-gamma-Secreting versus Interleukin-17-Secreting gammadelta T Cells. Immunity, 35:59-68. (PubMed:21737317)
  7. Yagi R et al. (2010) The transcription factor GATA3 actively represses RUNX3 protein-regulated production of interferon-gamma. Immunity, 32:507-17. (PubMed:20399120)
  8. Yoshihara S et al. (2005) Arx homeobox gene is essential for development of mouse olfactory system. Development, 132:751-62. (PubMed:15677725)



Go Annotations in Tabular Form (Text View) (GO Graph)

 
 


Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment
  IC Inferred by curator
  IDA Inferred from direct assay
  IEA Inferred from electronic annotation
  IGI Inferred from genetic interaction
  IMP Inferred from mutant phenotype
  IPI Inferred from physical interaction
  ISS Inferred from sequence or structural similarity
  ISO Inferred from sequence orthology
  ISA Inferred from sequence alignment
  ISM Inferred from sequence model
  NAS Non-traceable author statement
  ND No biological data available
  RCA Reviewed computational analysis
  TAS Traceable author statement


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
09/09/2014
MGI 5.19
The Jackson Laboratory