Go Annotations as Summary Text (Tabular View) (GO Graph)

GO curators for mouse genes have assigned the following annotations to the gene product of Lmbr1. (This text reflects annotations as of Tuesday, May 21, 2013.)

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Summary from NCBI RefSeq

This gene encodes a member of the LMBR1-like membrane protein family. Another member of this protein family has been shown to be a lipocalin transmembrane receptor. A highly conserved, cis-acting regulatory module for the sonic hedgehog gene is located within an intron of this gene. Consequently, disruption of this genic region can alter sonic hedgehog expression and affect limb patterning, but it is not known if this gene functions directly in limb development. [provided by RefSeq, Jul 2008]

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Summary text based on GO annotations supported by experimental evidence in mouse

• Researchers have inferred, based on phenotypic analysis of mouse mutants, that the gene product of Lmbr1
  • participates in the following biological processes:
    • embryonic digit morphogenesis ^[1]

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Summary text based on GO annotations supported by experimental evidence in other organisms

• From comparative sequence analysis (see table for details), MGI curators have determined that the gene product of Lmbr1:
  • participates in the following biological processes:
    • embryonic hindlimb morphogenesis

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Summary text for additional MGI annotations

• Automated translation to GO terms of SwissProt keywords that describe Lmbr1 indicates that it:
  • is located in the following cellular components:
    • integral to membrane
    • membrane

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References

1. Clark RM et al. (2001) Reciprocal mouse and human limb phenotypes caused by gain- and loss-of-function mutations affecting lmbr1. Genetics, 159:715-26. (PubMed:11606546)

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Gene Ontology Evidence Code Abbreviations:

EXP Inferred from experiment

IC Inferred by curator

IDA Inferred from direct assay

IEA Inferred from electronic annotation

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

ISS Inferred from sequence or structural similarity

ISO Inferred from sequence orthology

ISA Inferred from sequence alignment

ISM Inferred from sequence model

NAS Non-traceable author statement

ND No biological data available

RCA Reviewed computational analysis

TAS Traceable author statement

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