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Gene Ontology Classifications
Symbol
Name
ID
Klk4
kallikrein related-peptidase 4 (prostase, enamel matrix, prostate)
MGI:1861379

Go Annotations as Summary Text (Tabular View) (GO Graph)

GO curators for mouse genes have assigned the following annotations to the gene product of Klk4. (This text reflects annotations as of Thursday, July 24, 2014.) MGI curation of this mouse gene is considered complete, including annotations derived from the biomedical literature as of September 5, 2013. If you know of any additional information regarding this mouse gene please let us know. Please supply mouse gene symbol and a PubMed ID.
Summary from NCBI RefSeq


[Summary is not available for the mouse gene. This summary is for the human ortholog.] Kallikreins are a subgroup of serine proteases having diverse physiological functions. Growing evidence suggests that many kallikreins are implicated in carcinogenesis and some have potential as novel cancer and other disease biomarkers. This gene is one of the fifteen kallikrein subfamily members located in a cluster on chromosome 19. In some tissues its expression is hormonally regulated. The expression pattern of a similar mouse protein in murine developing teeth supports a role for the protein in the degradation of enamel proteins. Alternate splice variants for this gene have been described, but their biological validity has not been determined. [provided by RefSeq, Jul 2008]
Summary text based on GO annotations supported by experimental evidence in mouse
Summary text based on GO annotations supported by experimental evidence in other organisms
Summary text for additional MGI annotations
References
  1. Simmer JP et al. (2009) Hypomaturation enamel defects in Klk4 knockout/LacZ knockin mice. J Biol Chem, 284:19110-21. (PubMed:19578120)
  2. Smith CE et al. (2011) Effect of Kallikrein 4 Loss on Enamel Mineralization: COMPARISON WITH MICE LACKING MATRIX METALLOPROTEINASE 20. J Biol Chem, 286:18149-60. (PubMed:21454549)
  3. Yamakoshi Y et al. (2011) Enamel proteins and proteases in Mmp20 and Klk4 null and double-null mice. Eur J Oral Sci, 119 Suppl 1:206-16. (PubMed:22243248)



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Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment
  IC Inferred by curator
  IDA Inferred from direct assay
  IEA Inferred from electronic annotation
  IGI Inferred from genetic interaction
  IMP Inferred from mutant phenotype
  IPI Inferred from physical interaction
  ISS Inferred from sequence or structural similarity
  ISO Inferred from sequence orthology
  ISA Inferred from sequence alignment
  ISM Inferred from sequence model
  NAS Non-traceable author statement
  ND No biological data available
  RCA Reviewed computational analysis
  TAS Traceable author statement


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
12/23/2014
MGI 5.20
The Jackson Laboratory