Go Annotations as Summary Text (Tabular View) (GO Graph)

GO curators for mouse genes have assigned the following annotations to the gene product of Gabbr1. (This text reflects annotations as of Thursday, July 24, 2014.)

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Summary from NCBI RefSeq

[Summary is not available for the mouse gene. This summary is for the human ortholog.] Gamma-aminobutyric acid (GABA) is the main inhibitory neurotransmitter in the mammalian central nervous system. GABA exerts its effects through ionotropic [GABA(A/C)] receptors, to produce fast synaptic inhibition, and metabotropic [GABA(B)] receptors, to produce slow, prolonged inhibitory signals. The GABA(B) receptor consists of a heterodimer of two related 7-transmembrane receptors, GABA(B) receptor 1 and GABA(B) receptor 2. The GABA(B) receptor 1 gene is mapped to chromosome 6p21.3 within the HLA class I region close to the HLA-F gene. Susceptibility loci for multiple sclerosis, epilepsy, and schizophrenia have also been mapped in this region. Alternative splicing of this gene generates multiple transcript variants. [provided by RefSeq, Jun 2009]

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Summary text based on GO annotations supported by experimental evidence in mouse

• Researchers have inferred from direct assay, that the gene product of Gabbr1
  • participates in the following biological processes:
    • gamma-aminobutyric acid signaling pathway ^[2]
  • is located in the following cellular components:
    • cytoplasm ^[1]
    • G-protein coupled receptor dimeric complex ^[2]
    • membrane ^[2]
    • postsynaptic membrane ^[2]
    • presynaptic membrane ^[2]
• The gene product of Gabbr1 has been shown to bind to the gene products of Atf4, Kctd12. ^{[1, 2]}

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Summary text based on GO annotations supported by experimental evidence in other organisms

• From comparative sequence analysis (see table for details), MGI curators have determined that the gene product of Gabbr1:
  • participates in the following biological processes:
    • adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway
    • gamma-aminobutyric acid signaling pathway
    • negative regulation of adenylate cyclase activity
    • negative regulation of cell proliferation
    • negative regulation of dopamine secretion
    • negative regulation of epinephrine secretion
    • negative regulation of gamma-aminobutyric acid secretion
    • negative regulation of synaptic transmission
    • osteoblast differentiation
    • positive regulation of glutamate secretion
    • positive regulation of growth hormone secretion
    • regulation of cAMP biosynthetic process
    • regulation of glutamate secretion
  • performs the following molecular functions:
    • G-protein coupled GABA receptor activity
    • transcription factor binding
  • is located in the following cellular components:
    • axolemma
    • dendritic shaft
    • dendritic spine
    • endoplasmic reticulum membrane
    • extracellular space
    • G-protein coupled receptor heterodimeric complex
    • integral component of plasma membrane
    • intracellular membrane-bounded organelle
    • membrane raft
    • mitochondrial membrane
    • neuron projection
    • neuronal cell body
    • synaptic vesicle

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Summary text based on GO annotations supported by structural data

• Gabbr1 encodes a protein or proteins that contain the following InterPro domains: Extracellular ligand-binding receptor, GPCR, family 3, GPCR, family 3, C-terminal, GPCR, family 3, gamma-aminobutyric acid receptor, type B, GPCR, family 3, gamma-aminobutyric acid receptor, type B1, Sushi/SCR/CCP, indicating that the gene product:
  • participates in the following biological processes:
    • G-protein coupled receptor signaling pathway
  • performs the following molecular functions:
    • G-protein coupled receptor activity
  • is located in the following cellular components:
    • integral component of membrane

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Summary text for additional MGI annotations

• Automated translation to GO terms of SwissProt keywords that describe Gabbr1 indicates that it:
  • participates in the following biological processes:
    • G-protein coupled receptor signaling pathway
    • signal transduction
  • performs the following molecular functions:
    • G-protein coupled receptor activity
    • signal transducer activity
  • is located in the following cellular components:
    • cell junction
    • cell projection
    • integral component of membrane
    • plasma membrane
    • synapse

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References

1. Ritter B et al. (2004) The GABA(B) receptor subunits R1 and R2 interact differentially with the activation transcription factor ATF4 in mouse brain during the postnatal development. Brain Res Dev Brain Res, 149:73-7. (PubMed:15013631)
2. Schwenk J et al. (2010) Native GABA(B) receptors are heteromultimers with a family of auxiliary subunits. Nature, 465:231-5. (PubMed:20400944)

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Gene Ontology Evidence Code Abbreviations:

EXP Inferred from experiment

IC Inferred by curator

IDA Inferred from direct assay

IEA Inferred from electronic annotation

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

ISS Inferred from sequence or structural similarity

ISO Inferred from sequence orthology

ISA Inferred from sequence alignment

ISM Inferred from sequence model

NAS Non-traceable author statement

ND No biological data available

RCA Reviewed computational analysis

TAS Traceable author statement

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