Automated description from the Alliance of Genome Resources (Release 3.2)
Predicted to have several functions, including DNA-binding transcription activator activity, RNA polymerase II-specific; I-SMAD binding activity; and ubiquitin protein ligase binding activity. Involved in several processes, including animal organ development; protein phosphorylation; and transmembrane receptor protein serine/threonine kinase signaling pathway. Localizes to cytoplasm and nucleus. Is expressed in several structures, including alimentary system; egg cylinder; embryo mesenchyme; heart; and urinary system. Used to study primary pulmonary hypertension. Human ortholog(s) of this gene implicated in primary pulmonary hypertension. Orthologous to human SMAD9 (SMAD family member 9).