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Gene Ontology Classifications
Symbol
Name
ID
Smad9
SMAD family member 9
MGI:1859993

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GO curators for mouse genes have assigned the following annotations to the gene product of Smad9. (This text reflects annotations as of Thursday, July 24, 2014.)
Summary from NCBI RefSeq


This gene encodes a member of a family of proteins that act as downstream effectors of the bone morphogenetic protein (BMP) signaling pathway. The encoded protein is phosphorylated by BMP receptors, which stimulates its binding to SMAD4 and translocation into the nucleus, where it functions as a regulator of transcription. Activity of this protein is important for embryonic development. Mutation of this gene results in defects in pulmonary vasculature. [provided by RefSeq, Mar 2013]
Summary text based on GO annotations supported by experimental evidence in mouse
Summary text based on GO annotations supported by experimental evidence in other organisms
Summary text based on GO annotations supported by structural data
Summary text for additional MGI annotations
References
  1. Caubit X et al. (2008) Teashirt 3 is necessary for ureteral smooth muscle differentiation downstream of SHH and BMP4. Development, 135:3301-10. (PubMed:18776146)
  2. Cho A et al. (2008) FKBP8 cell-autonomously controls neural tube patterning through a Gli2- and Kif3a-dependent mechanism. Dev Biol, 321:27-39. (PubMed:18590716)
  3. Hester M et al. (2005) Smad1 and Smad8 function similarly in mammalian central nervous system development. Mol Cell Biol, 25:4683-92. (PubMed:15899870)
  4. Morikawa Y et al. (2009) BMP signaling regulates sympathetic nervous system development through Smad4-dependent and -independent pathways. Development, 136:3575-84. (PubMed:19793887)
  5. Park S et al. (2004) B-cell translocation gene 2 (Btg2) regulates vertebral patterning by modulating bone morphogenetic protein/smad signaling. Mol Cell Biol, 24:10256-62. (PubMed:15542835)
  6. Retting KN et al. (2009) BMP canonical Smad signaling through Smad1 and Smad5 is required for endochondral bone formation. Development, 136:1093-104. (PubMed:19224984)
  7. Yoshida Y et al. (2000) Negative regulation of BMP/Smad signaling by Tob in osteoblasts. Cell, 103:1085-97. (PubMed:11163184)
  8. Zhao M et al. (2009) Inhibition of microtubule assembly in osteoblasts stimulates bone morphogenetic protein 2 expression and bone formation through transcription factor Gli2. Mol Cell Biol, 29:1291-305. (PubMed:19103752)



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Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment
  IC Inferred by curator
  IDA Inferred from direct assay
  IEA Inferred from electronic annotation
  IGI Inferred from genetic interaction
  IMP Inferred from mutant phenotype
  IPI Inferred from physical interaction
  ISS Inferred from sequence or structural similarity
  ISO Inferred from sequence orthology
  ISA Inferred from sequence alignment
  ISM Inferred from sequence model
  NAS Non-traceable author statement
  ND No biological data available
  RCA Reviewed computational analysis
  TAS Traceable author statement


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
09/09/2014
MGI 5.19
The Jackson Laboratory