Go Annotations as Summary Text (Tabular View) (GO Graph)

GO curators for mouse genes have assigned the following annotations to the gene product of Cdc20. (This text reflects annotations as of Wednesday, January 23, 2013.)

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Summary from NCBI RefSeq

[Summary is not available for the mouse gene. This summary is for the human ortholog.] CDC20 appears to act as a regulatory protein interacting with several other proteins at multiple points in the cell cycle. It is required for two microtubule-dependent processes, nuclear movement prior to anaphase and chromosome separation. [provided by RefSeq, Jul 2008]

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Summary text based on GO annotations supported by experimental evidence in mouse

• Researchers have inferred from direct assay, that the gene product of Cdc20
  • participates in the following biological processes:
    • positive regulation of synapse maturation ^[5]
    • positive regulation of synaptic plasticity ^[5]
• The gene product of Cdc20 has been shown to bind to the gene products of Fbxo5, Neurod2, Sirt2. ^{[1, 2, 3, 4, 5]}
• Researchers have inferred, based on genetic interactions, that the gene product of Cdc20
  • participates in the following biological processes:
    • regulation of meiosis based on interactions with Fbxo43 ^[4]

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Summary text based on GO annotations supported by experimental evidence in other organisms

• From comparative sequence analysis (see table for details), MGI curators have determined that the gene product of Cdc20:
  • participates in the following biological processes:
    • activation of anaphase-promoting complex activity
    • anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process
    • positive regulation of cell proliferation
    • regulation of dendrite development
  • performs the following molecular functions:
    • enzyme binding
    • protein C-terminus binding
  • is located in the following cellular components:
    • centrosome
    • perinuclear region of cytoplasm
    • protein complex

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Summary text for additional MGI annotations

• Automated translation to GO terms of SwissProt keywords that describe Cdc20 indicates that it:
  • participates in the following biological processes:
    • cell cycle
    • cell differentiation
    • cell division
    • mitosis
    • nervous system development
  • is located in the following cellular components:
    • cytoplasm
    • cytoskeleton

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References

1. Goto M et al. (2004) Speriolin is a novel spermatogenic cell-specific centrosomal protein associated with the seventh WD motif of Cdc20. J Biol Chem, 279:42128-38. (PubMed:15280373)
2. Kim HS et al. (2011) SIRT2 Maintains Genome Integrity and Suppresses Tumorigenesis through Regulating APC/C Activity. Cancer Cell, 20:487-99. (PubMed:22014574)
3. Paronetto MP et al. (2004) Functional interaction between p90(Rsk2) and Emi1 contributes to the metaphase arrest of mouse oocytes. EMBO J, 23:4649-4659. (PubMed:15526037)
4. Shoji S et al. (2006) Mammalian Emi2 mediates cytostatic arrest and transduces the signal for meiotic exit via Cdc20. EMBO J, 25:834-45. (PubMed:16456547)
5. Yang Y et al. (2009) A Cdc20-APC ubiquitin signaling pathway regulates presynaptic differentiation. Science, 326:575-8. (PubMed:19900895)

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Gene Ontology Evidence Code Abbreviations:

EXP Inferred from experiment

IC Inferred by curator

IDA Inferred from direct assay

IEA Inferred from electronic annotation

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

ISS Inferred from sequence or structural similarity

ISO Inferred from sequence orthology

ISA Inferred from sequence alignment

ISM Inferred from sequence model

NAS Non-traceable author statement

ND No biological data available

RCA Reviewed computational analysis

TAS Traceable author statement

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