Automated description from the Alliance of Genome Resources (Release 3.0)
Predicted to have cytoskeletal protein binding activity and protein domain specific binding activity. Involved in several processes, including JNK cascade; myoblast fusion; and positive regulation of actin filament polymerization. Localizes to cell projection; focal adhesion; and plasma membrane. Used to study nephrotic syndrome. Human ortholog(s) of this gene implicated in nephrotic syndrome type 1. Is expressed in central nervous system and metanephros. Orthologous to human NPHS1 (NPHS1 adhesion molecule, nephrin).