Go Annotations as Summary Text (Tabular View) (GO Graph)

GO curators for mouse genes have assigned the following annotations to the gene product of Pdgfc. (This text reflects annotations as of Tuesday, May 21, 2013.)

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Summary from NCBI RefSeq

[Summary is not available for the mouse gene. This summary is for the human ortholog.] The protein encoded by this gene is a member of the platelet-derived growth factor family. The four members of this family are mitogenic factors for cells of mesenchymal origin and are characterized by a core motif of eight cysteines. This gene product appears to form only homodimers. It differs from the platelet-derived growth factor alpha and beta polypeptides in having an unusual N-terminal domain, the CUB domain. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Sep 2010]

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Summary text based on GO annotations supported by experimental evidence in mouse

• Researchers have inferred from direct assay, that the gene product of Pdgfc
  • participates in the following biological processes:
    • activation of transmembrane receptor protein tyrosine kinase activity ^[3]
    • cellular response to amino acid stimulus ^[4]
    • platelet-derived growth factor receptor signaling pathway ^[2]
    • positive regulation of cell proliferation ^{[3, 6]}
    • regulation of peptidyl-tyrosine phosphorylation ^[5]
  • performs the following molecular functions:
    • platelet-derived growth factor receptor binding ^{[2, 3]}
  • is located in the following cellular components:
    • extracellular region ^[3]
• Researchers have inferred, based on phenotypic analysis of mouse mutants, that the gene product of Pdgfc
  • participates in the following biological processes:
    • organ morphogenesis ^[1]
• Researchers have inferred, based on genetic interactions, that the gene product of Pdgfc
  • participates in the following biological processes:
    • organ morphogenesis based on interactions with Pdgfa ^[1]

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Summary text based on GO annotations supported by experimental evidence in other organisms

• From comparative sequence analysis (see table for details), MGI curators have determined that the gene product of Pdgfc:
  • participates in the following biological processes:
    • platelet-derived growth factor receptor signaling pathway
    • positive regulation of DNA replication
    • positive regulation of fibroblast proliferation
  • performs the following molecular functions:
    • cell surface binding
    • platelet-derived growth factor receptor binding
    • protein homodimerization activity
  • is located in the following cellular components:
    • extracellular space

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Summary text based on GO annotations supported by structural data

• Pdgfc encodes a protein or proteins that contain the following InterPro domains: CUB domain, Platelet-derived growth factor (PDGF), indicating that the gene product:
  • performs the following molecular functions:
    • growth factor activity
  • is located in the following cellular components:
    • membrane

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Summary text for additional MGI annotations

• Automated translation to GO terms of SwissProt keywords that describe Pdgfc indicates that it:
  • participates in the following biological processes:
    • multicellular organismal development
    • positive regulation of cell division
  • performs the following molecular functions:
    • growth factor activity
  • is located in the following cellular components:
    • cytoplasm
    • nucleus

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References

1. Ding H et al. (2004) A specific requirement for PDGF-C in palate formation and PDGFR-alpha signaling. Nat Genet, 36:1111-6. (PubMed:15361870)
2. Fredriksson L et al. (2004) Tissue plasminogen activator is a potent activator of PDGF-CC. EMBO J, 23:3793-802. (PubMed:15372073)
3. Li X et al. (2000) PDGF-C is a new protease-activated ligand for the PDGF alpha-receptor [see comments] Nat Cell Biol, 2:302-9. (PubMed:10806482)
4. Pogribny IP et al. (2010) Difference in expression of hepatic microRNAs miR-29c, miR-34a, miR-155, and miR-200b is associated with strain-specific susceptibility to dietary nonalcoholic steatohepatitis in mice. Lab Invest, 90:1437-46. (PubMed:20548288)
5. Saito Y et al. (2002) Protein kinase C-alpha and protein kinase C-epsilon are required for Grb2-associated binder-1 tyrosine phosphorylation in response to platelet-derived growth factor. J Biol Chem, 277:23216-22. (PubMed:11940581)
6. Simpson RJ et al. (2004) A classic zinc finger from friend of GATA mediates an interaction with the coiled-coil of transforming acidic coiled-coil 3. J Biol Chem, 279:39789-97. (PubMed:15234987)

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Gene Ontology Evidence Code Abbreviations:

EXP Inferred from experiment

IC Inferred by curator

IDA Inferred from direct assay

IEA Inferred from electronic annotation

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

ISS Inferred from sequence or structural similarity

ISO Inferred from sequence orthology

ISA Inferred from sequence alignment

ISM Inferred from sequence model

NAS Non-traceable author statement

ND No biological data available

RCA Reviewed computational analysis

TAS Traceable author statement

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