Automated description from the Alliance of Genome Resources
Exhibits Notch binding activity. Involved in several processes, including circulatory system development; negative regulation of blood vessel endothelial cell migration; and regulation of Notch signaling pathway. Predicted to localize to the integral component of plasma membrane. Human ortholog(s) of this gene implicated in Adams-Oliver syndrome. Is expressed in several structures, including cardiovascular system; central nervous system; early conceptus; intestine; and sensory organ. Orthologous to human DLL4 (delta like canonical Notch ligand 4).