Go Annotations as Summary Text (Tabular View) (GO Graph)

GO curators for mouse genes have assigned the following annotations to the gene product of Unc93b1. (This text reflects annotations as of Thursday, July 24, 2014.)

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Summary from NCBI RefSeq

[Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a protein that is involved in innate and adaptive immune response by regulating toll-like receptor signaling. The encoded protein traffics nucleotide sensing toll-like receptors to the endolysosome from the endoplasmic reticulum. Deficiency of the encoded protein has been associated with herpes simplex encephalitis. [provided by RefSeq, Feb 2014]

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Summary text based on GO annotations supported by experimental evidence in mouse

• Researchers have inferred from direct assay, that the gene product of Unc93b1
  • is located in the following cellular components:
    • early phagosome ^[2]
    • endoplasmic reticulum ^{[1, 4]}
    • endosome ^[2]
    • lysosome ^[2]
• Researchers have inferred, based on physical interactions, that the gene product of Unc93b1
  • performs the following molecular functions:
    • Toll-like receptor binding ^[1]
• Researchers have inferred, based on phenotypic analysis of mouse mutants, that the gene product of Unc93b1
  • participates in the following biological processes:
    • antigen processing and presentation of exogenous peptide antigen via MHC class II ^[4]
    • intracellular protein transport ^[2]
    • toll-like receptor 3 signaling pathway ^[4]
    • toll-like receptor 7 signaling pathway ^[4]
    • toll-like receptor 9 signaling pathway ^[4]
    • toll-like receptor signaling pathway ^[4]
  • is located in the following cellular components:
    • cell ^[2]
    • intracellular ^[2]

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Summary text based on GO annotations supported by experimental evidence in other organisms

• From comparative sequence analysis (see table for details), MGI curators have determined that the gene product of Unc93b1:
  • participates in the following biological processes:
    • toll-like receptor 3 signaling pathway
    • toll-like receptor 7 signaling pathway
    • toll-like receptor 9 signaling pathway
  • is located in the following cellular components:
    • endoplasmic reticulum
    • endosome

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Summary text for additional MGI annotations

• Automated translation to GO terms of SwissProt keywords that describe Unc93b1 indicates that it:
  • participates in the following biological processes:
    • defense response to virus
    • immune system process
    • innate immune response
  • is located in the following cellular components:
    • cytoplasmic vesicle
    • integral component of membrane
    • membrane

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References

1. Brinkmann MM et al. (2007) The interaction between the ER membrane protein UNC93B and TLR3, 7, and 9 is crucial for TLR signaling. J Cell Biol, 177:265-75. (PubMed:17452530)
2. Kim YM et al. (2008) UNC93B1 delivers nucleotide-sensing toll-like receptors to endolysosomes. Nature, 452:234-8. (PubMed:18305481)
3. Li S et al. (2011) Mapping a dynamic innate immunity protein interaction network regulating type I interferon production. Immunity, 35:426-40. (PubMed:21903422)
4. Tabeta K et al. (2006) The Unc93b1 mutation 3d disrupts exogenous antigen presentation and signaling via Toll-like receptors 3, 7 and 9 Nat Immunol, 7:156-64. (PubMed:16415873)

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Gene Ontology Evidence Code Abbreviations:

EXP Inferred from experiment

IC Inferred by curator

IDA Inferred from direct assay

IEA Inferred from electronic annotation

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

ISS Inferred from sequence or structural similarity

ISO Inferred from sequence orthology

ISA Inferred from sequence alignment

ISM Inferred from sequence model

NAS Non-traceable author statement

ND No biological data available

RCA Reviewed computational analysis

TAS Traceable author statement

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