Go Annotations as Summary Text (Tabular View) (GO Graph)

GO curators for mouse genes have assigned the following annotations to the gene product of Avpr1a. (This text reflects annotations as of Wednesday, January 23, 2013.)

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Summary from NCBI RefSeq

This gene encodes a receptor for arginine vasopressin, a neurohypophyseal hormone involved in diuresis inhibition, smooth muscle contraction, liver glycogenolysis stimulation and regulation of adrenocorticotropic hormone release from the pituitary. This receptor represents one of three G protein-coupled arginine vasopressin receptors which functions through a phosphotidylinositol-calcium second messenger system in vascular and hepatic tissues [provided by RefSeq, Jul 2008]

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Summary text based on GO annotations supported by experimental evidence in mouse

• Researchers have inferred, based on genetic interactions, that the gene product of Avpr1a
  • participates in the following biological processes:
    • regulation of systemic arterial blood pressure by vasopressin based on interactions with Avpr1b, Drd5 ^[1]

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Summary text based on GO annotations supported by experimental evidence in other organisms

• From comparative sequence analysis (see table for details), MGI curators have determined that the gene product of Avpr1a:
  • participates in the following biological processes:
    • calcium-mediated signaling
    • elevation of cytosolic calcium ion concentration
    • grooming behavior
    • maternal aggressive behavior
    • maternal behavior
    • negative regulation of female receptivity
    • negative regulation of transmission of nerve impulse
    • penile erection
    • positive regulation of blood pressure
    • positive regulation of cell growth
    • positive regulation of cell proliferation
    • positive regulation of cellular pH reduction
    • positive regulation of glutamate secretion
    • positive regulation of heart rate
    • positive regulation of prostaglandin biosynthetic process
    • positive regulation of renal sodium excretion
    • positive regulation of systemic arterial blood pressure
    • positive regulation of vasoconstriction
    • response to inorganic substance
    • response to organic substance
    • response to stress
    • social behavior
    • sperm ejaculation
  • performs the following molecular functions:
    • peptide hormone binding
    • V1A vasopressin receptor binding
    • vasopressin receptor activity
  • is located in the following cellular components:
    • cytoplasmic vesicle
    • plasma membrane

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Summary text based on GO annotations supported by structural data

• Avpr1a encodes a protein or proteins that contain the following InterPro domains: Domain of unknown function DUF1856, GPCR, rhodopsin-like, GPCR, rhodopsin-like, 7TM, Vasopressin receptor, Vasopressin V1A receptor, indicating that the gene product:
  • participates in the following biological processes:
    • G-protein coupled receptor signaling pathway
  • is located in the following cellular components:
    • integral to membrane

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Summary text for additional MGI annotations

• Automated translation to GO terms of SwissProt keywords that describe Avpr1a indicates that it:
  • participates in the following biological processes:
    • G-protein coupled receptor signaling pathway
    • signal transduction
  • performs the following molecular functions:
    • G-protein coupled receptor activity
    • signal transducer activity
  • is located in the following cellular components:
    • integral to membrane
    • membrane

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References

1. Hollon TR et al. (2002) Mice lacking D5 dopamine receptors have increased sympathetic tone and are hypertensive. J Neurosci, 22:10801-10. (PubMed:12486173)

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Gene Ontology Evidence Code Abbreviations:

EXP Inferred from experiment

IC Inferred by curator

IDA Inferred from direct assay

IEA Inferred from electronic annotation

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

ISS Inferred from sequence or structural similarity

ISO Inferred from sequence orthology

ISA Inferred from sequence alignment

ISM Inferred from sequence model

NAS Non-traceable author statement

ND No biological data available

RCA Reviewed computational analysis

TAS Traceable author statement

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