Go Annotations as Summary Text (Tabular View) (GO Graph)

GO curators for mouse genes have assigned the following annotations to the gene product of Cacng4. (This text reflects annotations as of Wednesday, January 23, 2013.)

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Summary from NCBI RefSeq

[Summary is not available for the mouse gene. This summary is for the human ortholog.] The protein encoded by this gene is a type I transmembrane AMPA receptor regulatory protein (TARP). TARPs regulate both trafficking and channel gating of the AMPA receptors. This gene is part of a functionally diverse eight-member protein subfamily of the PMP-22/EMP/MP20 family and is located in a cluster with two family members, a type II TARP and a calcium channel gamma subunit. [provided by RefSeq, Dec 2010]

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Summary text based on GO annotations supported by experimental evidence in mouse

• Researchers have inferred from direct assay, that the gene product of Cacng4
  • is located in the following cellular components:
    • alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid selective glutamate receptor complex ^[3]
• Researchers have inferred, based on phenotypic analysis of mouse mutants, that the gene product of Cacng4
  • participates in the following biological processes:
    • regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity ^[2]
• Researchers have inferred, based on genetic interactions, that the gene product of Cacng4
  • participates in the following biological processes:
    • transmission of nerve impulse based on interactions with Cacng2 ^[1]

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Summary text based on GO annotations supported by experimental evidence in other organisms

• From comparative sequence analysis (see table for details), MGI curators have determined that the gene product of Cacng4:
  • participates in the following biological processes:
    • regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity
  • is located in the following cellular components:
    • alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid selective glutamate receptor complex

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Summary text based on GO annotations supported by structural data

• Cacng4 encodes a protein or proteins that contain the following InterPro domains: PMP-22/EMP/MP20/Claudin, Voltage-dependent calcium channel, gamma subunit, Voltage-dependent calcium channel, gamma-4 subunit, indicating that the gene product:
  • participates in the following biological processes:
    • calcium ion transmembrane transport
    • calcium ion transport
  • performs the following molecular functions:
    • voltage-gated calcium channel activity
  • is located in the following cellular components:
    • membrane
    • voltage-gated calcium channel complex

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Summary text for additional MGI annotations

• Automated translation to GO terms of SwissProt keywords that describe Cacng4 indicates that it:
  • participates in the following biological processes:
    • calcium ion transmembrane transport
    • calcium ion transport
    • ion transport
    • regulation of ion transmembrane transport
    • transport
  • performs the following molecular functions:
    • calcium channel activity
    • ion channel activity
    • voltage-gated ion channel activity
  • is located in the following cellular components:
    • integral to membrane
    • membrane
    • plasma membrane

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References

1. Letts VA et al. (2005) A targeted mutation in Cacng4 exacerbates spike-wave seizures in stargazer (Cacng2) mice. Proc Natl Acad Sci U S A, 102:2123-8. (PubMed:15677329)
2. Milstein AD et al. (2007) TARP subtypes differentially and dose-dependently control synaptic AMPA receptor gating. Neuron, 55:905-18. (PubMed:17880894)
3. Schwenk J et al. (2012) High-resolution proteomics unravel architecture and molecular diversity of native AMPA receptor complexes. Neuron, 74:621-33. (PubMed:22632720)

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Gene Ontology Evidence Code Abbreviations:

EXP Inferred from experiment

IC Inferred by curator

IDA Inferred from direct assay

IEA Inferred from electronic annotation

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

ISS Inferred from sequence or structural similarity

ISO Inferred from sequence orthology

ISA Inferred from sequence alignment

ISM Inferred from sequence model

NAS Non-traceable author statement

ND No biological data available

RCA Reviewed computational analysis

TAS Traceable author statement

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