Go Annotations as Summary Text (Tabular View) (GO Graph)

GO curators for mouse genes have assigned the following annotations to the gene product of Pla2g6. (This text reflects annotations as of Wednesday, January 23, 2013.)

---

Summary from NCBI RefSeq

[Summary is not available for the mouse gene. This summary is for the human ortholog.] The protein encoded by this gene is an A2 phospholipase, a class of enzyme that catalyzes the release of fatty acids from phospholipids. The encoded protein may play a role in phospholipid remodelling, arachidonic acid release, leukotriene and prostaglandin synthesis, fas-mediated apoptosis, and transmembrane ion flux in glucose-stimulated B-cells. Several transcript variants encoding multiple isoforms have been described, but the full-length nature of only three of them have been determined to date. [provided by RefSeq, Dec 2010]

---

Summary text based on GO annotations supported by experimental evidence in other organisms

• From comparative sequence analysis (see table for details), MGI curators have determined that the gene product of Pla2g6:
  • participates in the following biological processes:
    • cardiolipin biosynthetic process
    • elevation of cytosolic calcium ion concentration
    • memory
    • negative regulation of synaptic transmission, glutamatergic
    • positive regulation of arachidonic acid secretion
    • positive regulation of ceramide biosynthetic process
    • positive regulation of exocytosis
    • positive regulation of insulin secretion involved in cellular response to glucose stimulus
    • positive regulation of protein kinase C signaling cascade
    • positive regulation of protein phosphorylation
    • positive regulation of release of cytochrome c from mitochondria
    • positive regulation of vasodilation
    • regulation of store-operated calcium channel activity
    • response to endoplasmic reticulum stress
    • urinary bladder smooth muscle contraction
  • performs the following molecular functions:
    • ATP-dependent protein binding
    • calcium-independent phospholipase A2 activity
  • is located in the following cellular components:
    • centrosome
    • cytoplasm
    • cytosol
    • mitochondrion

---

Summary text based on GO annotations supported by structural data

• Pla2g6 encodes a protein or proteins that contain the following InterPro domains: Acyl transferase/acyl hydrolase/lysophospholipase, Ankyrin repeat, Ankyrin repeat-containing domain, Patatin/Phospholipase A2-related, indicating that the gene product:
  • participates in the following biological processes:
    • lipid metabolic process
    • metabolic process

---

Summary text for additional MGI annotations

• Automated translation to GO terms of SwissProt keywords that describe Pla2g6 indicates that it:
  • participates in the following biological processes:
    • chemotaxis
    • lipid catabolic process
    • lipid metabolic process
  • performs the following molecular functions:
    • calmodulin binding
    • hydrolase activity
  • is located in the following cellular components:
    • membrane
• Pla2g6 has been associated with the Enzyme Commission numbers: 3.1.1.4, which implies that the gene product:
  • performs the following molecular functions:
    • phospholipase A2 activity

---

---

Gene Ontology Evidence Code Abbreviations:

EXP Inferred from experiment

IC Inferred by curator

IDA Inferred from direct assay

IEA Inferred from electronic annotation

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

ISS Inferred from sequence or structural similarity

ISO Inferred from sequence orthology

ISA Inferred from sequence alignment

ISM Inferred from sequence model

NAS Non-traceable author statement

ND No biological data available

RCA Reviewed computational analysis

TAS Traceable author statement

---