Go Annotations as Summary Text (Tabular View) (GO Graph)

GO curators for mouse genes have assigned the following annotations to the gene product of Fut8. (This text reflects annotations as of Wednesday, January 23, 2013.) MGI curation of this mouse gene is considered complete, including annotations derived from the biomedical literature as of May 15, 2007. If you know of any additional information regarding this mouse gene please let us know. Please supply mouse gene symbol and a PubMed ID.

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Summary from NCBI RefSeq

[Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes an enzyme belonging to the family of fucosyltransferases. The product of this gene catalyzes the transfer of fucose from GDP-fucose to N-linked type complex glycopeptides. This enzyme is distinct from other fucosyltransferases which catalyze alpha1-2, alpha1-3, and alpha1-4 fucose addition. The expression of this gene may contribute to the malignancy of cancer cells and to their invasive and metastatic capabilities. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2011]

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Summary text based on GO annotations supported by experimental evidence in mouse

• Researchers have inferred, based on phenotypic analysis of mouse mutants, that the gene product of Fut8
  • participates in the following biological processes:
    • cell migration ^[2]
    • fucosylation ^{[1, 2]}
    • integrin-mediated signaling pathway ^[2]
    • receptor metabolic process ^[1]
    • respiratory gaseous exchange ^[1]
    • transforming growth factor beta receptor signaling pathway ^[1]
  • performs the following molecular functions:
    • alpha-(1->6)-fucosyltransferase activity ^{[1, 2]}

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Summary text based on GO annotations supported by experimental evidence in other organisms

• From comparative sequence analysis (see table for details), MGI curators have determined that the gene product of Fut8:
  • participates in the following biological processes:
    • metabolic process
  • performs the following molecular functions:
    • transferase activity, transferring glycosyl groups

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Summary text based on GO annotations supported by structural data

• Fut8 encodes a protein or proteins that contain the following InterPro domains: Alpha-(1,6)-fucosyltransferase, eukaryotic type, Src homology-3 domain, indicating that the gene product:
  • participates in the following biological processes:
    • N-glycan fucosylation
    • protein glycosylation in Golgi
  • performs the following molecular functions:
    • glycoprotein 6-alpha-L-fucosyltransferase activity
  • is located in the following cellular components:
    • Golgi cisterna membrane
    • integral to membrane

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Summary text for additional MGI annotations

• Automated translation to GO terms of SwissProt keywords that describe Fut8 indicates that it:
  • performs the following molecular functions:
    • SH3 domain binding
    • transferase activity
  • is located in the following cellular components:
    • Golgi apparatus
    • integral to membrane
    • membrane
• Fut8 has been associated with the Enzyme Commission numbers: 2.4.1.68, which implies that the gene product:
  • participates in the following biological processes:
    • N-glycan fucosylation
  • performs the following molecular functions:
    • glycoprotein 6-alpha-L-fucosyltransferase activity

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References

1. Wang X et al. (2005) Dysregulation of TGF-beta1 receptor activation leads to abnormal lung development and emphysema-like phenotype in core fucose-deficient mice. Proc Natl Acad Sci U S A, 102:15791-6. (PubMed:16236725)
2. Zhao Y et al. (2006) Deletion of core fucosylation on alpha3beta1 integrin down-regulates its functions. J Biol Chem, 281:38343-50. (PubMed:17043354)

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Gene Ontology Evidence Code Abbreviations:

EXP Inferred from experiment

IC Inferred by curator

IDA Inferred from direct assay

IEA Inferred from electronic annotation

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

ISS Inferred from sequence or structural similarity

ISO Inferred from sequence orthology

ISA Inferred from sequence alignment

ISM Inferred from sequence model

NAS Non-traceable author statement

ND No biological data available

RCA Reviewed computational analysis

TAS Traceable author statement

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