Go Annotations as Summary Text (Tabular View) (GO Graph)

GO curators for mouse genes have assigned the following annotations to the gene product of Icos. (This text reflects annotations as of Tuesday, May 21, 2013.)

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Summary from NCBI RefSeq

[Summary is not available for the mouse gene. This summary is for the human ortholog.] The protein encoded by this gene belongs to the CD28 and CTLA-4 cell-surface receptor family. It forms homodimers and plays an important role in cell-cell signaling, immune responses, and regulation of cell proliferation. [provided by RefSeq, Jul 2008]

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Summary text based on GO annotations supported by experimental evidence in mouse

• Researchers have inferred from direct assay, that the gene product of Icos
  • is located in the following cellular components:
    • external side of plasma membrane ^{[1, 2, 4]}
    • integral to plasma membrane ^[4]
• The gene product of Icos has been shown to bind to the gene products of Icosl. ^{[3, 4]}

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Summary text for additional MGI annotations

• Automated translation to GO terms of SwissProt keywords that describe Icos indicates that it:
  • is located in the following cellular components:
    • integral to membrane
    • membrane

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References

1. Abe J et al. (2008) Increased Foxp3(+) CD4(+) regulatory T cells with intact suppressive activity but altered cellular localization in murine lupus. Am J Pathol, 173:1682-92. (PubMed:19008373)
2. Fontenot JD et al. (2005) A function for interleukin 2 in Foxp3-expressing regulatory T cells. Nat Immunol, 6:1142-51. (PubMed:16227984)
3. Ling V et al. (2000) Cutting edge: identification of GL50, a novel B7-like protein that functionally binds to ICOS receptor. J Immunol, 164:1653-7. (PubMed:10657606)
4. Mages HW et al. (2000) Molecular cloning and characterization of murine ICOS and identification of B7h as ICOS ligand. Eur J Immunol, 30:1040-7. (PubMed:10760791)

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Gene Ontology Evidence Code Abbreviations:

EXP Inferred from experiment

IC Inferred by curator

IDA Inferred from direct assay

IEA Inferred from electronic annotation

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

ISS Inferred from sequence or structural similarity

ISO Inferred from sequence orthology

ISA Inferred from sequence alignment

ISM Inferred from sequence model

NAS Non-traceable author statement

ND No biological data available

RCA Reviewed computational analysis

TAS Traceable author statement

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