Automated description from the Alliance of Genome Resources (Release 3.0)
Predicted to have DNA-binding transcription factor activity and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in negative regulation of transcription by RNA polymerase II. Predicted to localize to nucleus. Human ortholog(s) of this gene implicated in MHC class II deficiency and severe combined immunodeficiency. Is expressed in several structures, including branchial arch; eye; genitourinary system; heart; and nervous system. Orthologous to human RFX5 (regulatory factor X5).