Go Annotations as Summary Text (Tabular View) (GO Graph)

GO curators for mouse genes have assigned the following annotations to the gene product of Celsr2. (This text reflects annotations as of Tuesday, July 8, 2014.)

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Summary from NCBI RefSeq

[Summary is not available for the mouse gene. This summary is for the human ortholog.] The protein encoded by this gene is a member of the flamingo subfamily, part of the cadherin superfamily. The flamingo subfamily consists of nonclassic-type cadherins; a subpopulation that does not interact with catenins. The flamingo cadherins are located at the plasma membrane and have nine cadherin domains, seven epidermal growth factor-like repeats and two laminin A G-type repeats in their ectodomain. They also have seven transmembrane domains, a characteristic unique to this subfamily. It is postulated that these proteins are receptors involved in contact-mediated communication, with cadherin domains acting as homophilic binding regions and the EGF-like domains involved in cell adhesion and receptor-ligand interactions. The specific function of this particular member has not been determined. [provided by RefSeq, Jul 2008]

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Summary text based on GO annotations supported by experimental evidence in mouse

• Researchers have inferred from direct assay, that the gene product of Celsr2
  • participates in the following biological processes:
    • homophilic cell adhesion ^[]
    • neural plate anterior/posterior regionalization ^[]
    • regulation of transcription, DNA-templated ^[]
    • Wnt signaling pathway ^[]
  • is located in the following cellular components:
    • cytoplasm ^[]
    • plasma membrane ^[]
• Researchers have inferred, based on phenotypic analysis of mouse mutants, that the gene product of Celsr2
  • participates in the following biological processes:
    • cilium assembly ^[]
    • cilium movement ^[]
    • neuron migration ^[]
    • regulation of protein localization ^[]
    • ventricular system development ^[]
• Researchers have inferred, based on genetic interactions, that the gene product of Celsr2
  • participates in the following biological processes:
    • cerebrospinal fluid secretion based on interactions with Celsr3 ^[]
    • cilium assembly based on interactions with Celsr3 ^[]
    • regulation of protein localization based on interactions with Celsr3 ^[]

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Summary text based on GO annotations supported by experimental evidence in other organisms

• From comparative sequence analysis (see table for details), MGI curators have determined that the gene product of Celsr2:
  • participates in the following biological processes:
    • dendrite morphogenesis
    • regulation of cell-cell adhesion
  • is located in the following cellular components:
    • plasma membrane

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Summary text based on GO annotations supported by structural data

• Celsr2 encodes a protein or proteins that contain the following InterPro domains: indicating that the gene product:
  • participates in the following biological processes:
    • cell adhesion
    • cell surface receptor signaling pathway
    • G-protein coupled receptor signaling pathway
    • neuropeptide signaling pathway
  • performs the following molecular functions:
    • calcium ion binding
    • G-protein coupled receptor activity
    • transmembrane signaling receptor activity
  • is located in the following cellular components:
    • integral component of membrane
    • membrane

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Summary text for additional MGI annotations

• Automated translation to GO terms of SwissProt keywords that describe Celsr2 indicates that it:
  • participates in the following biological processes:
    • G-protein coupled receptor signaling pathway
    • multicellular organismal development
    • signal transduction
  • performs the following molecular functions:
    • G-protein coupled receptor activity
    • signal transducer activity
  • is located in the following cellular components:
    • integral component of membrane
    • membrane

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References

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Gene Ontology Evidence Code Abbreviations:

EXP Inferred from experiment

IC Inferred by curator

IDA Inferred from direct assay

IEA Inferred from electronic annotation

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

ISS Inferred from sequence or structural similarity

ISO Inferred from sequence orthology

ISA Inferred from sequence alignment

ISM Inferred from sequence model

NAS Non-traceable author statement

ND No biological data available

RCA Reviewed computational analysis

TAS Traceable author statement

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