Go Annotations as Summary Text (Tabular View) (GO Graph)

GO curators for mouse genes have assigned the following annotations to the gene product of Celsr2. (This text reflects annotations as of Wednesday, January 23, 2013.)

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Summary from NCBI RefSeq

[Summary is not available for the mouse gene. This summary is for the human ortholog.] The protein encoded by this gene is a member of the flamingo subfamily, part of the cadherin superfamily. The flamingo subfamily consists of nonclassic-type cadherins; a subpopulation that does not interact with catenins. The flamingo cadherins are located at the plasma membrane and have nine cadherin domains, seven epidermal growth factor-like repeats and two laminin A G-type repeats in their ectodomain. They also have seven transmembrane domains, a characteristic unique to this subfamily. It is postulated that these proteins are receptors involved in contact-mediated communication, with cadherin domains acting as homophilic binding regions and the EGF-like domains involved in cell adhesion and receptor-ligand interactions. The specific function of this particular member has not been determined. [provided by RefSeq, Jul 2008]

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Summary text based on GO annotations supported by experimental evidence in mouse

• Researchers have inferred from direct assay, that the gene product of Celsr2
  • participates in the following biological processes:
    • homophilic cell adhesion ^[4]
    • neural plate anterior/posterior regionalization ^[2]
    • regulation of transcription, DNA-dependent ^[2]
    • Wnt receptor signaling pathway ^[2]
  • is located in the following cellular components:
    • cytoplasm ^[1]
    • plasma membrane ^[1]
• Researchers have inferred, based on phenotypic analysis of mouse mutants, that the gene product of Celsr2
  • participates in the following biological processes:
    • cilium assembly ^[5]
    • cilium movement ^[5]
    • neuron migration ^[3]
    • regulation of protein localization ^[5]
    • ventricular system development ^[6]
• Researchers have inferred, based on genetic interactions, that the gene product of Celsr2
  • participates in the following biological processes:
    • cerebrospinal fluid secretion based on interactions with Celsr3 ^[5]
    • cilium assembly based on interactions with Celsr3 ^[5]
    • regulation of protein localization based on interactions with Celsr3 ^[5]

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Summary text based on GO annotations supported by experimental evidence in other organisms

• From comparative sequence analysis (see table for details), MGI curators have determined that the gene product of Celsr2:
  • participates in the following biological processes:
    • dendrite morphogenesis
    • regulation of cell-cell adhesion
  • is located in the following cellular components:
    • plasma membrane

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Summary text based on GO annotations supported by structural data

• Celsr2 encodes a protein or proteins that contain the following InterPro domains: Cadherin, Cadherin conserved site, Cadherin-like, Concanavalin A-like lectin/glucanase, subgroup, Concanavalin A-like lectin/glucanases superfamily, Domain of unknown function DUF3497, EGF-like calcium-binding, EGF-like, conserved site, EGF-like, laminin, EGF-type aspartate/asparagine hydroxylation site, Epidermal growth factor-like domain, GPCR, family 2, extracellular hormone receptor domain, GPCR, family 2, secretin-like, GPCR, family 2-like, GPS domain, Laminin G domain, TNFR/NGFR cysteine-rich region, indicating that the gene product:
  • participates in the following biological processes:
    • cell adhesion
    • cell surface receptor signaling pathway
    • G-protein coupled receptor signaling pathway
    • neuropeptide signaling pathway
  • performs the following molecular functions:
    • calcium ion binding
    • G-protein coupled receptor activity
    • transmembrane signaling receptor activity
  • is located in the following cellular components:
    • integral to membrane
    • membrane

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Summary text for additional MGI annotations

• Automated translation to GO terms of SwissProt keywords that describe Celsr2 indicates that it:
  • participates in the following biological processes:
    • G-protein coupled receptor signaling pathway
    • multicellular organismal development
    • signal transduction
  • performs the following molecular functions:
    • G-protein coupled receptor activity
    • signal transducer activity
  • is located in the following cellular components:
    • integral to membrane
    • membrane

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References

1. Lahousse SA et al. (2006) Mono-(2-ethylhexyl) phthalate rapidly increases celsr2 protein phosphorylation in HeLa cells via protein kinase C and casein kinase 1. Toxicol Sci, 91:255-64. (PubMed:16484285)
2. Morgan R et al. (2003) Flamingo, a cadherin-type receptor involved in the Drosophila planar polarity pathway, can block signaling via the canonical wnt pathway in Xenopus laevis. Int J Dev Biol, 47:245-52. (PubMed:12755329)
3. Qu Y et al. (2010) Atypical cadherins Celsr1-3 differentially regulate migration of facial branchiomotor neurons in mice. J Neurosci, 30:9392-401. (PubMed:20631168)
4. Shima Y et al. (2004) Regulation of dendritic maintenance and growth by a mammalian 7-pass transmembrane cadherin. Dev Cell, 7:205-16. (PubMed:15296717)
5. Tissir F et al. (2010) Lack of cadherins Celsr2 and Celsr3 impairs ependymal ciliogenesis, leading to fatal hydrocephalus. Nat Neurosci, 13:700-7. (PubMed:20473291)
6. Vogel P et al. (2012) Congenital hydrocephalus in genetically engineered mice. Vet Pathol, 49:166-81. (PubMed:21746835)

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Gene Ontology Evidence Code Abbreviations:

EXP Inferred from experiment

IC Inferred by curator

IDA Inferred from direct assay

IEA Inferred from electronic annotation

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

ISS Inferred from sequence or structural similarity

ISO Inferred from sequence orthology

ISA Inferred from sequence alignment

ISM Inferred from sequence model

NAS Non-traceable author statement

ND No biological data available

RCA Reviewed computational analysis

TAS Traceable author statement

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