Go Annotations as Summary Text (Tabular View) (GO Graph)

GO curators for mouse genes have assigned the following annotations to the gene product of Sept9. (This text reflects annotations as of Wednesday, January 23, 2013.)

---

Summary from NCBI RefSeq

[Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene is a member of the septin family involved in cytokinesis and cell cycle control. This gene is a candidate for the ovarian tumor suppressor gene. Mutations in this gene cause hereditary neuralgic amyotrophy, also known as neuritis with brachial predilection. A chromosomal translocation involving this gene on chromosome 17 and the MLL gene on chromosome 11 results in acute myelomonocytic leukemia. Multiple alternatively spliced transcript variants encoding different isoforms have been described.[provided by RefSeq, Mar 2009]

---

Summary text based on GO annotations supported by experimental evidence in other organisms

• From comparative sequence analysis (see table for details), MGI curators have determined that the gene product of Sept9:
  • participates in the following biological processes:
    • protein heterooligomerization
  • is located in the following cellular components:
    • actin cytoskeleton
    • microtubule
    • perinuclear region of cytoplasm
    • stress fiber

---

Summary text based on GO annotations supported by structural data

• Sept9 encodes a protein or proteins that contain the following InterPro domains: Cell division protein GTP binding, Septin, Small GTP-binding protein domain, indicating that the gene product:
  • participates in the following biological processes:
    • cell cycle
  • performs the following molecular functions:
    • GTP binding

---

Summary text for additional MGI annotations

• Automated translation to GO terms of SwissProt keywords that describe Sept9 indicates that it:
  • participates in the following biological processes:
    • cell cycle
    • cell division
  • performs the following molecular functions:
    • GTP binding
    • nucleotide binding
  • is located in the following cellular components:
    • cytoplasm
    • cytoskeleton

---

---

Gene Ontology Evidence Code Abbreviations:

EXP Inferred from experiment

IC Inferred by curator

IDA Inferred from direct assay

IEA Inferred from electronic annotation

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

ISS Inferred from sequence or structural similarity

ISO Inferred from sequence orthology

ISA Inferred from sequence alignment

ISM Inferred from sequence model

NAS Non-traceable author statement

ND No biological data available

RCA Reviewed computational analysis

TAS Traceable author statement

---