Automated description from the Alliance of Genome Resources (Release 7.0.0)
Predicted to enable interleukin-1 receptor binding activity and pattern recognition receptor activity. Predicted to be involved in inflammatory response; pattern recognition receptor signaling pathway; and positive regulation of nitric oxide biosynthetic process. Predicted to act upstream of or within innate immune response. Predicted to be located in membrane. Is expressed in central nervous system; sensory organ; and trunk unsegmented mesenchyme. Human ortholog(s) of this gene implicated in Legionnaires' disease; cystic fibrosis; cystitis; melioidosis; and systemic lupus erythematosus. Orthologous to human TLR5 (toll like receptor 5).