Go Annotations as Summary Text (Tabular View) (GO Graph)

GO curators for mouse genes have assigned the following annotations to the gene product of Olig2. (This text reflects annotations as of Wednesday, January 23, 2013.)

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Summary from NCBI RefSeq

[Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a basic helix-loop-helix transcription factor which is expressed in oligodendroglial tumors of the brain. The protein is an essential regulator of ventral neuroectodermal progenitor cell fate. The gene is involved in a chromosomal translocation t(14;21)(q11.2;q22) associated with T-cell acute lymphoblastic leukemia. Its chromosomal location is within a region of chromosome 21 which has been suggested to play a role in learning deficits associated with Down syndrome. [provided by RefSeq, Jul 2008]

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Summary text based on GO annotations supported by experimental evidence in mouse

• Researchers have inferred from direct assay, that the gene product of Olig2
  • participates in the following biological processes:
    • negative regulation of neuron differentiation ^[7]
    • negative regulation of transcription from RNA polymerase II promoter ^[3]
    • nervous system development ^[8]
    • regulation of transcription, DNA-dependent ^[8]
    • spinal cord oligodendrocyte cell fate specification ^[6]
  • performs the following molecular functions:
    • RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity ^[3]
    • sequence-specific DNA binding transcription factor activity ^[8]
  • is located in the following cellular components:
    • cytoplasm ^[8]
    • nucleus ^{[2, 8]}
• The gene product of Olig2 has been shown to bind to the gene products of Id2, Id4. ^[5] Researchers have inferred, based on physical interactions, that the gene product of Olig2
  • performs the following molecular functions:
    • HMG box domain binding ^[9]
    • protein homodimerization activity ^[3]
• Researchers have inferred, based on phenotypic analysis of mouse mutants, that the gene product of Olig2
  • participates in the following biological processes:
    • myelination ^[10]
    • neuron fate commitment ^[4]
    • oligodendrocyte differentiation ^[10]
    • spinal cord motor neuron differentiation ^[1]
• Researchers have inferred, based on genetic interactions, that the gene product of Olig2
  • participates in the following biological processes:
    • positive regulation of oligodendrocyte differentiation based on interactions with Nkx2-2 ^[7]
    • spinal cord oligodendrocyte cell differentiation based on interactions with Ascl1 ^[6]

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Summary text based on GO annotations supported by experimental evidence in other organisms

• From comparative sequence analysis (see table for details), MGI curators have determined that the gene product of Olig2:
  • participates in the following biological processes:
    • regulation of transcription, DNA-dependent
  • performs the following molecular functions:
    • sequence-specific DNA binding transcription factor activity
  • is located in the following cellular components:
    • transcription factor complex

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Summary text based on GO annotations supported by structural data

• Olig2 encodes a protein or proteins that contain the following InterPro domains: Helix-loop-helix domain, indicating that the gene product:
  • performs the following molecular functions:
    • protein dimerization activity

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Summary text for additional MGI annotations

• Automated translation to GO terms of SwissProt keywords that describe Olig2 indicates that it:
  • participates in the following biological processes:
    • multicellular organismal development
    • transcription, DNA-dependent
  • performs the following molecular functions:
    • DNA binding

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References

1. Chen JA et al. (2011) Mir-17-3p controls spinal neural progenitor patterning by regulating Olig2/Irx3 cross-repressive loop. Neuron, 69:721-35. (PubMed:21338882)
2. Flandin P et al. (2010) The progenitor zone of the ventral medial ganglionic eminence requires Nkx2-1 to generate most of the globus pallidus but few neocortical interneurons. J Neurosci, 30:2812-23. (PubMed:20181579)
3. Lee SK et al. (2005) Olig2 and Ngn2 function in opposition to modulate gene expression in motor neuron progenitor cells. Genes Dev, 19:282-94. (PubMed:15655114)
4. Lu QR et al. (2002) Common developmental requirement for olig function indicates a motor neuron/oligodendrocyte connection. Cell, 109:75-86. (PubMed:11955448)
5. Samanta J et al. (2004) Interactions between ID and OLIG proteins mediate the inhibitory effects of BMP4 on oligodendroglial differentiation. Development, 131:4131-42. (PubMed:15280210)
6. Sugimori M et al. (2008) Ascl1 is required for oligodendrocyte development in the spinal cord. Development, 135:1271-81. (PubMed:18287202)
7. Sun T et al. (2001) Olig bHLH proteins interact with homeodomain proteins to regulate cell fate acquisition in progenitors of the ventral neural tube. Curr Biol, 11:1413-20. (PubMed:11566099)
8. Sun T et al. (2003) Cross-repressive interaction of the Olig2 and Nkx2.2 transcription factors in developing neural tube associated with formation of a specific physical complex. J Neurosci, 23:9547-56. (PubMed:14573534)
9. Wissmuller S et al. (2006) The high-mobility-group domain of Sox proteins interacts with DNA-binding domains of many transcription factors. Nucleic Acids Res, 34:1735-44. (PubMed:16582099)
10. Yue T et al. (2006) A critical role for dorsal progenitors in cortical myelination. J Neurosci, 26:1275-80. (PubMed:16436615)

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Gene Ontology Evidence Code Abbreviations:

EXP Inferred from experiment

IC Inferred by curator

IDA Inferred from direct assay

IEA Inferred from electronic annotation

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

ISS Inferred from sequence or structural similarity

ISO Inferred from sequence orthology

ISA Inferred from sequence alignment

ISM Inferred from sequence model

NAS Non-traceable author statement

ND No biological data available

RCA Reviewed computational analysis

TAS Traceable author statement

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