Automated description from the Alliance of Genome Resources (Release 3.1.1)
Exhibits phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity. Involved in several processes, including dephosphorylation; regulation of postsynaptic neurotransmitter receptor internalization; and vesicle-mediated transport in synapse. Localizes to Schaffer collateral - CA1 synapse; glutamatergic synapse; and membrane coat. Predicted to colocalize with microtubule. Is expressed in several structures, including central nervous system; genitourinary system; peripheral nervous system; respiratory system; and sensory organ. Human ortholog(s) of this gene implicated in Parkinson's disease; Parkinson's disease 20; and early infantile epileptic encephalopathy 53. Orthologous to human SYNJ1 (synaptojanin 1).