Automated description from the Alliance of Genome Resources
Exhibits phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity. Involved in several processes, including dephosphorylation; regulation of postsynaptic neurotransmitter receptor internalization; and vesicle-mediated transport in synapse. Localizes to the Schaffer collateral - CA1 synapse; glutamatergic synapse; and membrane coat. Predicted to colocalize with the microtubule. Human ortholog(s) of this gene implicated in Parkinson's disease; early infantile epileptic encephalopathy 53; and early-onset Parkinson's disease 20. Orthologous to human SYNJ1 (synaptojanin 1).