Automated description from the Alliance of Genome Resources (Release 5.3.0)
Enables protein-disulfide reductase activity. Involved in intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress and release of sequestered calcium ion into cytosol. Acts upstream of or within several processes, including brown fat cell differentiation; cell redox homeostasis; and peptidyl-proline hydroxylation to 4-hydroxy-L-proline. Predicted to be located in several cellular components, including Golgi lumen; dendrite; and endoplasmic reticulum. Predicted to be active in endoplasmic reticulum membrane. Orthologous to human ERO1A (endoplasmic reticulum oxidoreductase 1 alpha).