Automated description from the Alliance of Genome Resources (Release 7.0.0)
Enables protein tyrosine kinase binding activity and superoxide-generating NAD(P)H oxidase activity. Involved in several processes, including cellular response to glucose stimulus; positive regulation of intracellular signal transduction; and superoxide anion generation. Acts upstream of or within bone resorption and cardiac muscle cell differentiation. Located in cell periphery; mitochondrion; and perinuclear region of cytoplasm. Is expressed in embryo; heart; metanephros; renal cortex; and ventricle compact myocardium. Orthologous to human NOX4 (NADPH oxidase 4).