Automated description from the Alliance of Genome Resources (Release 3.1.1)
Exhibits protein tyrosine kinase binding activity and superoxide-generating NADPH oxidase activity. Involved in several processes, including bone resorption; positive regulation of protein kinase B signaling; and positive regulation of protein phosphorylation. Localizes to several cellular components, including mitochondrion; nucleus; and perinuclear region of cytoplasm. Predicted to colocalize with stress fiber. Is expressed in embryo; heart; metanephros; renal cortex; and ventricle compact myocardium. Orthologous to human NOX4 (NADPH oxidase 4).