Go Annotations as Summary Text (Tabular View) (GO Graph)

GO curators for mouse genes have assigned the following annotations to the gene product of Ercc4. (This text reflects annotations as of Tuesday, May 21, 2013.) MGI curation of this mouse gene is considered complete, including annotations derived from the biomedical literature as of October 12, 2007. If you know of any additional information regarding this mouse gene please let us know. Please supply mouse gene symbol and a PubMed ID.

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Summary from NCBI RefSeq

[Summary is not available for the mouse gene. This summary is for the human ortholog.] The protein encoded by this gene forms a complex with ERCC1 and is involved in the 5' incision made during nucleotide excision repair. This complex is a structure specific DNA repair endonuclease that interacts with EME1. Defects in this gene are a cause of xeroderma pigmentosum complementation group F (XP-F), or xeroderma pigmentosum VI (XP6).[provided by RefSeq, Mar 2009]

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Summary text based on GO annotations supported by experimental evidence in mouse

• Researchers have inferred from direct assay, that the gene product of Ercc4
  • performs the following molecular functions:
    • TFIID-class transcription factor binding ^[2]
  • is located in the following cellular components:
    • transcription factor TFIID complex ^[2]
• The gene product of Ercc4 has been shown to bind to the gene products of Ercc1. ^[1]
• Researchers have inferred, based on phenotypic analysis of mouse mutants, that the gene product of Ercc4
  • participates in the following biological processes:
    • DNA repair ^[3]
    • UV protection ^[3]

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Summary text based on GO annotations supported by experimental evidence in other organisms

• From comparative sequence analysis (see table for details), MGI curators have determined that the gene product of Ercc4:
  • participates in the following biological processes:
    • DNA repair
    • double-strand break repair via homologous recombination
    • meiotic mismatch repair
    • negative regulation of telomere maintenance
    • nucleotide-excision repair
    • nucleotide-excision repair, DNA incision
    • nucleotide-excision repair, DNA incision, 3'-to lesion
    • nucleotide-excision repair, DNA incision, 5'-to lesion
    • resolution of meiotic recombination intermediates
    • response to UV
    • telomere maintenance
    • telomere maintenance via telomere shortening
  • performs the following molecular functions:
    • damaged DNA binding
    • endodeoxyribonuclease activity
    • protein C-terminus binding
    • protein N-terminus binding
    • single-stranded DNA binding
    • single-stranded DNA specific endodeoxyribonuclease activity
    • structure-specific DNA binding
  • is located in the following cellular components:
    • chromosome, telomeric region
    • nuclear chromosome, telomeric region
    • nucleotide-excision repair complex
    • nucleotide-excision repair factor 1 complex
    • nucleus

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Summary text based on GO annotations supported by structural data

• Ercc4 encodes a protein or proteins that contain the following InterPro domains: DNA repair nuclease, XPF-type/Helicase, DNA repair protein, ERCC4 domain, Restriction endonuclease type II-like, RuvA domain 2-like, indicating that the gene product:
  • participates in the following biological processes:
    • DNA metabolic process
  • performs the following molecular functions:
    • DNA binding
    • endonuclease activity
    • nuclease activity
    • nucleic acid binding

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Summary text for additional MGI annotations

• Automated translation to GO terms of SwissProt keywords that describe Ercc4 indicates that it:
  • participates in the following biological processes:
    • response to DNA damage stimulus
  • performs the following molecular functions:
    • DNA binding
    • endonuclease activity
    • hydrolase activity
    • nuclease activity

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References

1. Chen J et al. (2012) Cathepsin cleavage of sirtuin 1 in endothelial progenitor cells mediates stress-induced premature senescence. Am J Pathol, 180:973-83. (PubMed:22234173)
2. Kamileri I et al. (2012) Defective transcription initiation causes postnatal growth failure in a mouse model of nucleotide excision repair (NER) progeria. Proc Natl Acad Sci U S A, 109:2995-3000. (PubMed:22323595)
3. Tian M et al. (2004) Growth retardation, early death, and DNA repair defects in mice deficient for the nucleotide excision repair enzyme XPF. Mol Cell Biol, 24:1200-5. (PubMed:14729965)

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Gene Ontology Evidence Code Abbreviations:

EXP Inferred from experiment

IC Inferred by curator

IDA Inferred from direct assay

IEA Inferred from electronic annotation

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

ISS Inferred from sequence or structural similarity

ISO Inferred from sequence orthology

ISA Inferred from sequence alignment

ISM Inferred from sequence model

NAS Non-traceable author statement

ND No biological data available

RCA Reviewed computational analysis

TAS Traceable author statement

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