Go Annotations as Summary Text (Tabular View) (GO Graph)

GO curators for mouse genes have assigned the following annotations to the gene product of Aass. (This text reflects annotations as of Wednesday, January 23, 2013.) MGI curation of this mouse gene is considered complete, including annotations derived from the biomedical literature as of January 21, 2009. If you know of any additional information regarding this mouse gene please let us know. Please supply mouse gene symbol and a PubMed ID.

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Summary from NCBI RefSeq

This gene encodes a bifunctional mitochondrial protein that catalyzes the first two steps in the lysine degradation pathway. The N-terminus contains lysine-ketoglutarate reductase activity and converts lysine to saccharopine, whereas the C-terminus contains saccharopine dehydrogenase activity and converts saccharopine to alpha-aminoadipate semialdehyde. Mutations in a human gene encoding a highly similar protein are associated with familial hyperlysinemia. [provided by RefSeq, Jul 2008]

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Summary text based on GO annotations supported by experimental evidence in mouse

• Researchers have inferred from direct assay, that the gene product of Aass
  • participates in the following biological processes:
    • L-lysine catabolic process ^[1]
    • oxidation-reduction process ^[1]
  • performs the following molecular functions:
    • saccharopine dehydrogenase (NAD+, L-glutamate-forming) activity ^[1]

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Summary text based on GO annotations supported by experimental evidence in other organisms

• From comparative sequence analysis (see table for details), MGI curators have determined that the gene product of Aass:
  • is located in the following cellular components:
    • cytoplasm
    • intracellular membrane-bounded organelle
    • mitochondrion

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Summary text based on GO annotations supported by structural data

• Aass encodes a protein or proteins that contain the following InterPro domains: Alanine dehydrogenase/PNT, NAD(H)-binding domain, Alanine dehydrogenase/pyridine nucleotide transhydrogenase, N-terminal, NAD(P)-binding domain, Saccharopine dehydrogenase / Homospermidine synthase, indicating that the gene product:
  • performs the following molecular functions:
    • nucleotide binding
    • oxidoreductase activity

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Summary text for additional MGI annotations

• Automated translation to GO terms of SwissProt keywords that describe Aass indicates that it:
  • participates in the following biological processes:
    • metabolic process
  • performs the following molecular functions:
    • catalytic activity
    • oxidoreductase activity
• Aass has been associated with the Enzyme Commission numbers: 1.5.1.8, 1.5.1.9, which implies that the gene product:
  • performs the following molecular functions:
    • saccharopine dehydrogenase (NADP+, L-lysine-forming) activity

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References

1. Papes F et al. (1999) Lysine degradation through the saccharopine pathway in mammals: involvement of both bifunctional and monofunctional lysine-degrading enzymes in mouse. Biochem J, 344 Pt 2:555-63. (PubMed:10567240)

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Gene Ontology Evidence Code Abbreviations:

EXP Inferred from experiment

IC Inferred by curator

IDA Inferred from direct assay

IEA Inferred from electronic annotation

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

ISS Inferred from sequence or structural similarity

ISO Inferred from sequence orthology

ISA Inferred from sequence alignment

ISM Inferred from sequence model

NAS Non-traceable author statement

ND No biological data available

RCA Reviewed computational analysis

TAS Traceable author statement

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