Go Annotations as Summary Text (Tabular View) (GO Graph)

GO curators for mouse genes have assigned the following annotations to the gene product of Foxe3. (This text reflects annotations as of Wednesday, January 23, 2013.)

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Summary from NCBI RefSeq

[Summary is not available for the mouse gene. This summary is for the human ortholog.] This intronless gene belongs to the forkhead family of transcription factors, which is characterized by a distinct forkhead domain. The protein encoded functions as a lens-specific transcription factor and plays an important role in vertebrate lens formation. Mutations in this gene are associated with anterior segment mesenchymal dysgenesis and congenital primary aphakia. [provided by RefSeq, Dec 2009]

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Summary text based on GO annotations supported by experimental evidence in mouse

• Researchers have inferred, based on phenotypic analysis of mouse mutants, that the gene product of Foxe3
  • participates in the following biological processes:
    • camera-type eye development ^[2]
    • cell development ^[3]
    • eye development ^[1]
    • positive regulation of epithelial cell proliferation ^[3]

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Summary text based on GO annotations supported by experimental evidence in other organisms

• From comparative sequence analysis (see table for details), MGI curators have determined that the gene product of Foxe3:
  • participates in the following biological processes:
    • cell migration
    • embryonic organ morphogenesis
    • enteric nervous system development
    • hair follicle morphogenesis
    • hard palate development
    • lens morphogenesis in camera-type eye
    • negative regulation of transcription from RNA polymerase II promoter
    • pattern specification process
    • peripheral nervous system development
    • positive regulation of transcription from RNA polymerase II promoter
    • regulation of sequence-specific DNA binding transcription factor activity
    • soft palate development
    • thyroid gland development
    • thyroid hormone generation
    • transcription from RNA polymerase II promoter
  • performs the following molecular functions:
    • DNA binding, bending
    • double-stranded DNA binding
    • RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity
    • sequence-specific DNA binding transcription factor activity
    • transcription factor binding
  • is located in the following cellular components:
    • transcription factor complex

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Summary text based on GO annotations supported by structural data

• Foxe3 encodes a protein or proteins that contain the following InterPro domains: Transcription factor, fork head, Transcription factor, fork head, conserved site, Winged helix-turn-helix transcription repressor DNA-binding, indicating that the gene product:
  • participates in the following biological processes:
    • regulation of transcription, DNA-dependent
  • performs the following molecular functions:
    • sequence-specific DNA binding

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Summary text for additional MGI annotations

• Automated translation to GO terms of SwissProt keywords that describe Foxe3 indicates that it:
  • participates in the following biological processes:
    • regulation of transcription, DNA-dependent
    • transcription, DNA-dependent
  • performs the following molecular functions:
    • DNA binding
  • is located in the following cellular components:
    • nucleus

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References

1. Blixt A et al. (2000) A forkhead gene, FoxE3, is essential for lens epithelial proliferation and closure of the lens vesicle. Genes Dev, 14:245-54. (PubMed:10652278)
2. Maeda YY et al. (2001) Two interactive genes responsible for a new inherited cataract (RCT) in the mouse. Mamm Genome, 12:278-83. (PubMed:11309658)
3. Medina-Martinez O et al. (2005) Severe defects in proliferation and differentiation of lens cells in Foxe3 null mice. Mol Cell Biol, 25:8854-63. (PubMed:16199865)

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Gene Ontology Evidence Code Abbreviations:

EXP Inferred from experiment

IC Inferred by curator

IDA Inferred from direct assay

IEA Inferred from electronic annotation

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

ISS Inferred from sequence or structural similarity

ISO Inferred from sequence orthology

ISA Inferred from sequence alignment

ISM Inferred from sequence model

NAS Non-traceable author statement

ND No biological data available

RCA Reviewed computational analysis

TAS Traceable author statement

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