Go Annotations as Summary Text (Tabular View) (GO Graph)

GO curators for mouse genes have assigned the following annotations to the gene product of Mmp20. (This text reflects annotations as of Wednesday, January 23, 2013.)

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Summary from NCBI RefSeq

[Summary is not available for the mouse gene. This summary is for the human ortholog.] Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMP's are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. The protein encoded by this gene degrades amelogenin, the major protein component of dental enamel matrix, and thus thought to play a role in tooth enamel formation. A mutation in this gene, which alters the normal splice pattern and results in premature termination of the encoded protein, has been associated with amelogenesis imperfecta. This gene is part of a cluster of MMP genes located on chromosome 11q22.3. [provided by RefSeq, Aug 2011]

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Summary text based on GO annotations supported by experimental evidence in mouse

• Researchers have inferred, based on phenotypic analysis of mouse mutants, that the gene product of Mmp20
  • participates in the following biological processes:
    • amelogenesis ^[1]

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Summary text based on GO annotations supported by structural data

• Mmp20 encodes a protein or proteins that contain the following InterPro domains: Hemopexin/matrixin, Hemopexin/matrixin, repeat, Metallopeptidase, catalytic domain, Peptidase M10, metallopeptidase, Peptidase M10A, cysteine switch, zinc binding site, Peptidase M10A, matrix metallopeptidase, Peptidase M10A, matrix metallopeptidase, stromelysin type, Peptidase, metallopeptidase, Peptidoglycan binding-like, indicating that the gene product:
  • participates in the following biological processes:
    • metabolic process
    • proteolysis
  • performs the following molecular functions:
    • calcium ion binding
    • metalloendopeptidase activity
    • metallopeptidase activity
    • zinc ion binding
  • is located in the following cellular components:
    • extracellular matrix

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Summary text for additional MGI annotations

• Automated translation to GO terms of SwissProt keywords that describe Mmp20 indicates that it:
  • participates in the following biological processes:
    • proteolysis
  • performs the following molecular functions:
    • hydrolase activity
    • metal ion binding
    • metallopeptidase activity
    • peptidase activity
  • is located in the following cellular components:
    • extracellular region
    • proteinaceous extracellular matrix

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References

1. Bartlett JD et al. (2004) Decreased mineral content in MMP-20 null mouse enamel is prominent during the maturation stage. J Dent Res, 83:909-13. (PubMed:15557396)

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Gene Ontology Evidence Code Abbreviations:

EXP Inferred from experiment

IC Inferred by curator

IDA Inferred from direct assay

IEA Inferred from electronic annotation

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

ISS Inferred from sequence or structural similarity

ISO Inferred from sequence orthology

ISA Inferred from sequence alignment

ISM Inferred from sequence model

NAS Non-traceable author statement

ND No biological data available

RCA Reviewed computational analysis

TAS Traceable author statement

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