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Gene Ontology Classifications
Symbol
Name
ID
Mmp20
matrix metallopeptidase 20 (enamelysin)
MGI:1353466

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GO curators for mouse genes have assigned the following annotations to the gene product of Mmp20. (This text reflects annotations as of Thursday, July 24, 2014.)
Summary from NCBI RefSeq


[Summary is not available for the mouse gene. This summary is for the human ortholog.] Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMP's are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. The protein encoded by this gene degrades amelogenin, the major protein component of dental enamel matrix, and thus thought to play a role in tooth enamel formation. A mutation in this gene, which alters the normal splice pattern and results in premature termination of the encoded protein, has been associated with amelogenesis imperfecta. This gene is part of a cluster of MMP genes located on chromosome 11q22.3. [provided by RefSeq, Aug 2011]
Summary text based on GO annotations supported by experimental evidence in mouse
Summary text based on GO annotations supported by structural data
Summary text for additional MGI annotations
References
  1. Bartlett JD et al. (2004) Decreased mineral content in MMP-20 null mouse enamel is prominent during the maturation stage. J Dent Res, 83:909-13. (PubMed:15557396)
  2. Smith CE et al. (2011) Effect of Kallikrein 4 Loss on Enamel Mineralization: COMPARISON WITH MICE LACKING MATRIX METALLOPROTEINASE 20. J Biol Chem, 286:18149-60. (PubMed:21454549)
  3. Yamakoshi Y et al. (2011) Enamel proteins and proteases in Mmp20 and Klk4 null and double-null mice. Eur J Oral Sci, 119 Suppl 1:206-16. (PubMed:22243248)



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Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment
  IC Inferred by curator
  IDA Inferred from direct assay
  IEA Inferred from electronic annotation
  IGI Inferred from genetic interaction
  IMP Inferred from mutant phenotype
  IPI Inferred from physical interaction
  ISS Inferred from sequence or structural similarity
  ISO Inferred from sequence orthology
  ISA Inferred from sequence alignment
  ISM Inferred from sequence model
  NAS Non-traceable author statement
  ND No biological data available
  RCA Reviewed computational analysis
  TAS Traceable author statement


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
08/12/2014
MGI 5.19
The Jackson Laboratory