Go Annotations as Summary Text (Tabular View) (GO Graph)

GO curators for mouse genes have assigned the following annotations to the gene product of Ulk2. (This text reflects annotations as of Wednesday, January 23, 2013.)

---

Summary from NCBI RefSeq

[Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a protein that is similar to a serine/threonine kinase in C. elegans which is involved in axonal elongation. The structure of this protein is similar to the C. elegans protein in that both proteins have an N-terminal kinase domain, a central proline/serine rich (PS) domain, and a C-terminal (C) domain. The gene is located within the Smith-Magenis syndrome region on chromosome 17. Alternatively spliced transcript variants encoding the same protein have been identified. [provided by RefSeq, Dec 2008]

---

Summary text based on GO annotations supported by experimental evidence in mouse

• Researchers have inferred from direct assay, that the gene product of Ulk2
  • participates in the following biological processes:
    • response to starvation ^[1]
  • performs the following molecular functions:
    • protein serine/threonine kinase activity ^[1]
  • is located in the following cellular components:
    • pre-autophagosomal structure membrane ^[1]
• The gene product of Ulk2 has been shown to bind to the gene products of Rb1cc1. ^[1]
• Researchers have inferred, based on phenotypic analysis of mouse mutants, that the gene product of Ulk2
  • participates in the following biological processes:
    • axon extension ^[2]
    • negative regulation of collateral sprouting ^[2]
    • regulation of autophagy ^[1]

---

Summary text based on GO annotations supported by experimental evidence in other organisms

• From comparative sequence analysis (see table for details), MGI curators have determined that the gene product of Ulk2:
  • participates in the following biological processes:
    • protein autophosphorylation
    • regulation of autophagy
  • performs the following molecular functions:
    • protein serine/threonine kinase activity
  • is located in the following cellular components:
    • pre-autophagosomal structure membrane

---

Summary text based on GO annotations supported by structural data

• Ulk2 encodes a protein or proteins that contain the following InterPro domains: Protein kinase, ATP binding site, Protein kinase, catalytic domain, Protein kinase-like domain, Serine/threonine- / dual-specificity protein kinase, catalytic domain, Serine/threonine-protein kinase, active site, Serine/threonine-protein kinase, C-terminal, Serine/threonine-protein kinase, Ulk1/Ulk2, indicating that the gene product:
  • participates in the following biological processes:
    • axonogenesis
    • protein phosphorylation
    • signal transduction
  • performs the following molecular functions:
    • ATP binding
    • protein kinase activity
    • transferase activity, transferring phosphorus-containing groups

---

Summary text for additional MGI annotations

• Automated translation to GO terms of SwissProt keywords that describe Ulk2 indicates that it:
  • participates in the following biological processes:
    • autophagy
    • nervous system development
    • phosphorylation
  • performs the following molecular functions:
    • ATP binding
    • kinase activity
    • nucleotide binding
    • transferase activity
  • is located in the following cellular components:
    • cytoplasmic vesicle
    • membrane

---

References

1. Hara T et al. (2008) FIP200, a ULK-interacting protein, is required for autophagosome formation in mammalian cells. J Cell Biol, 181:497-510. (PubMed:18443221)
2. Zhou X et al. (2007) Unc-51-like kinase 1/2-mediated endocytic processes regulate filopodia extension and branching of sensory axons. Proc Natl Acad Sci U S A, 104:5842-7. (PubMed:17389358)

---

---

Gene Ontology Evidence Code Abbreviations:

EXP Inferred from experiment

IC Inferred by curator

IDA Inferred from direct assay

IEA Inferred from electronic annotation

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

ISS Inferred from sequence or structural similarity

ISO Inferred from sequence orthology

ISA Inferred from sequence alignment

ISM Inferred from sequence model

NAS Non-traceable author statement

ND No biological data available

RCA Reviewed computational analysis

TAS Traceable author statement

---