Go Annotations as Summary Text (Tabular View) (GO Graph)

GO curators for mouse genes have assigned the following annotations to the gene product of Abcc8. (This text reflects annotations as of Wednesday, January 23, 2013.)

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Summary from NCBI RefSeq

[Summary is not available for the mouse gene. This summary is for the human ortholog.] The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MRP subfamily which is involved in multi-drug resistance. This protein functions as a modulator of ATP-sensitive potassium channels and insulin release. Mutations and deficiencies in this protein have been observed in patients with hyperinsulinemic hypoglycemia of infancy, an autosomal recessive disorder of unregulated and high insulin secretion. Mutations have also been associated with non-insulin-dependent diabetes mellitus type II, an autosomal dominant disease of defective insulin secretion. Alternative splicing of this gene has been observed; however, the transcript variants have not been fully described. [provided by RefSeq, Jul 2008]

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Summary text based on GO annotations supported by experimental evidence in mouse

• Researchers have inferred from direct assay, that the gene product of Abcc8
  • is located in the following cellular components:
    • plasma membrane ^[1]

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Summary text based on GO annotations supported by experimental evidence in other organisms

• From comparative sequence analysis (see table for details), MGI curators have determined that the gene product of Abcc8:
  • participates in the following biological processes:
    • negative regulation of insulin secretion
    • positive regulation of potassium ion transport
    • potassium ion transmembrane transport
    • response to chemical stimulus
    • response to pH
    • response to zinc ion
  • performs the following molecular functions:
    • ATP binding
    • ion channel binding
    • potassium channel activity
    • syntaxin binding
  • is located in the following cellular components:
    • sarcolemma
    • synaptic vesicle membrane
    • voltage-gated potassium channel complex

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Summary text for additional MGI annotations

• Automated translation to GO terms of SwissProt keywords that describe Abcc8 indicates that it:
  • performs the following molecular functions:
    • nucleotide binding

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References

1. Morrissey A et al. (2005) Expression of ATP-sensitive K+ channel subunits during perinatal maturation in the mouse heart. Pediatr Res, 58:185-92. (PubMed:16085792)

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Gene Ontology Evidence Code Abbreviations:

EXP Inferred from experiment

IC Inferred by curator

IDA Inferred from direct assay

IEA Inferred from electronic annotation

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

ISS Inferred from sequence or structural similarity

ISO Inferred from sequence orthology

ISA Inferred from sequence alignment

ISM Inferred from sequence model

NAS Non-traceable author statement

ND No biological data available

RCA Reviewed computational analysis

TAS Traceable author statement

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