About   Help   FAQ
Gene Ontology Classifications
Symbol
Name
ID
Esr1
estrogen receptor 1 (alpha)
MGI:1352467

Go Annotations as Summary Text (Tabular View) (GO Graph)

GO curators for mouse genes have assigned the following annotations to the gene product of Esr1. (This text reflects annotations as of Tuesday, July 8, 2014.)
Summary from NCBI RefSeq


[Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes an estrogen receptor, a ligand-activated transcription factor composed of several domains important for hormone binding, DNA binding, and activation of transcription. The protein localizes to the nucleus where it may form a homodimer or a heterodimer with estrogen receptor 2. Estrogen and its receptors are essential for sexual development and reproductive function, but also play a role in other tissues such as bone. Estrogen receptors are also involved in pathological processes including breast cancer, endometrial cancer, and osteoporosis. Alternative promoter usage and alternative splicing result in dozens of transcript variants, but the full-length nature of many of these variants has not been determined. [provided by RefSeq, Mar 2014]
Summary text based on GO annotations supported by experimental evidence in mouse
Summary text based on GO annotations supported by experimental evidence in other organisms
Summary text based on GO annotations supported by structural data
Summary text for additional MGI annotations
References
  1. . () , :. (PubMed:)
  2. . () , :. (PubMed:)
  3. . () , :. (PubMed:)
  4. . () , :. (PubMed:)
  5. . () , :. (PubMed:)
  6. . () , :. (PubMed:)
  7. . () , :. (PubMed:)
  8. . () , :. (PubMed:)
  9. . () , :. (PubMed:)
  10. . () , :. (PubMed:)
  11. . () , :. (PubMed:)
  12. . () , :. (PubMed:)
  13. . () , :. (PubMed:)
  14. . () , :. (PubMed:)
  15. . () , :. (PubMed:)
  16. . () , :. (PubMed:)
  17. . () , :. (PubMed:)
  18. . () , :. (PubMed:)
  19. . () , :. (PubMed:)
  20. . () , :. (PubMed:)
  21. . () , :. (PubMed:)



Go Annotations in Tabular Form (Text View) (GO Graph)

 
 


Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment
  IC Inferred by curator
  IDA Inferred from direct assay
  IEA Inferred from electronic annotation
  IGI Inferred from genetic interaction
  IMP Inferred from mutant phenotype
  IPI Inferred from physical interaction
  ISS Inferred from sequence or structural similarity
  ISO Inferred from sequence orthology
  ISA Inferred from sequence alignment
  ISM Inferred from sequence model
  NAS Non-traceable author statement
  ND No biological data available
  RCA Reviewed computational analysis
  TAS Traceable author statement


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
07/15/2014
MGI 5.18
The Jackson Laboratory