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Gene Ontology Classifications
estrogen receptor 1 (alpha)

Go Annotations as Summary Text (Tabular View) (GO Graph)

GO curators for mouse genes have assigned the following annotations to the gene product of Esr1. (This text reflects annotations as of Tuesday, May 26, 2015.)
Summary from NCBI RefSeq

[Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes an estrogen receptor, a ligand-activated transcription factor composed of several domains important for hormone binding, DNA binding, and activation of transcription. The protein localizes to the nucleus where it may form a homodimer or a heterodimer with estrogen receptor 2. Estrogen and its receptors are essential for sexual development and reproductive function, but also play a role in other tissues such as bone. Estrogen receptors are also involved in pathological processes including breast cancer, endometrial cancer, and osteoporosis. Alternative promoter usage and alternative splicing result in dozens of transcript variants, but the full-length nature of many of these variants has not been determined. [provided by RefSeq, Mar 2014]
Summary text based on GO annotations supported by experimental evidence in mouse
Summary text based on GO annotations supported by experimental evidence in other organisms
Summary text based on GO annotations supported by structural data
Summary text for additional MGI annotations
  1. Bocchinfuso WP et al. (2000) Induction of mammary gland development in estrogen receptor-alpha knockout mice. Endocrinology, 141:2982-94. (PubMed:10919287)
  2. Chen M et al. (2009) Defects of prostate development and reproductive system in the estrogen receptor-alpha null male mice. Endocrinology, 150:251-9. (PubMed:18755802)
  3. Chen YH et al. (2005) GAC63, a GRIP1-Dependent Nuclear Receptor Coactivator. Mol Cell Biol, 25:5965-72. (PubMed:15988012)
  4. Danilovich N et al. (2003) The menopausal mouse: a new neural paradigm of a distressing human condition. Neuroreport, 14:1617-22. (PubMed:14502087)
  5. Danilovich N et al. (2003) Age-related neurodegenerative changes in the central nervous system of estrogen-deficient follitropin receptor knockout mice. Exp Neurol, 183:559-72. (PubMed:14552897)
  6. Dupont S et al. (2000) Effect of single and compound knockouts of estrogen receptors alpha (ERalpha) and beta (ERbeta) on mouse reproductive phenotypes. Development, 127:4277-91. (PubMed:10976058)
  7. Gao S et al. (2013) NCOA5 haploinsufficiency results in glucose intolerance and subsequent hepatocellular carcinoma. Cancer Cell, 24:725-37. (PubMed:24332041)
  8. Jiang MS et al. (1997) A subpopulation of estrogen receptors are modified by O-linked N-acetylglucosamine. J Biol Chem, 272:2421-8. (PubMed:8999954)
  9. Khetchoumian K et al. (2004) TIF1delta, a novel HP1-interacting member of the transcriptional intermediary factor 1 (TIF1) family expressed by elongating spermatids. J Biol Chem, 279:48329-41. (PubMed:15322135)
  10. Kim SY et al. (2009) Foxl2, a forkhead transcription factor, modulates nonclassical activity of the estrogen receptor-alpha. Endocrinology, 150:5085-93. (PubMed:19797124)
  11. Le Douarin B et al. (1996) A possible involvement of TIF1 alpha and TIF1 beta in the epigenetic control of transcription by nuclear receptors. EMBO J, 15:6701-15. (PubMed:8978696)
  12. Lin VY et al. (2003) Truncated estrogen receptor product-1 stimulates estrogen receptor alpha transcriptional activity by titration of repressor proteins. J Biol Chem, 278:38125-31. (PubMed:12878603)
  13. Mak HY et al. (1999) Molecular determinants of the estrogen receptor-coactivator interface. Mol Cell Biol, 19:3895-903. (PubMed:10207113)
  14. Mueller SO et al. (2002) Mammary gland development in adult mice requires epithelial and stromal estrogen receptor alpha. Endocrinology, 143:2357-65. (PubMed:12021201)
  15. Mussi P et al. (2006) Haploinsufficiency of the corepressor of estrogen receptor activity (REA) enhances estrogen receptor function in the mammary gland. Proc Natl Acad Sci U S A, 103:16716-21. (PubMed:17065319)
  16. Omoto Y. (2008) Estrogen receptor-alpha signaling in growth of the ventral prostate: comparison of neonatal growth and postcastration regrowth. Endocrinology, 149:4421-7. (PubMed:18535112)
  17. Omoto Y et al. (2005) Estrogen receptor alpha and imprinting of the neonatal mouse ventral prostate by estrogen. Proc Natl Acad Sci U S A, 102:1484-9. (PubMed:15665095)
  18. Ray S et al. (2008) Cooperative Control via Lymphoid Enhancer Factor 1/T Cell Factor 3 and Estrogen Receptor-{alpha} for Uterine Gene Regulation by Estrogen. Mol Endocrinol, 22:1125-40. (PubMed:18202148)
  19. Shyamala G et al. (2002) Cellular expression of estrogen and progesterone receptors in mammary glands: regulation by hormones, development and aging. J Steroid Biochem Mol Biol, 80:137-48. (PubMed:11897499)
  20. Symonds D et al. (2003) Smad 3 regulates proliferation of the mouse ovarian surface epithelium. Anat Rec A Discov Mol Cell Evol Biol, 273:681-6. (PubMed:12845704)
  21. Uhlenhaut NH et al. (2009) Somatic sex reprogramming of adult ovaries to testes by FOXL2 ablation. Cell, 139:1130-42. (PubMed:20005806)
  22. Yin Y et al. (2008) Estrogen suppresses uterine epithelial apoptosis by inducing birc1 expression. Mol Endocrinol, 22:113-25. (PubMed:17901126)

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Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment
  IAS Inferred from ancestral sequence
  IBA Inferred from biological aspect of ancestor
  IBD Inferred from biological aspect of descendant
  IC Inferred by curator
  IDA Inferred from direct assay
  IEA Inferred from electronic annotation
  IGI Inferred from genetic interaction
  IKR Inferred from key residues
  IMP Inferred from mutant phenotype
  IMR Inferred from missing residues
  IPI Inferred from physical interaction
  IRD Inferred from rapid divergence
  ISS Inferred from sequence or structural similarity
  ISO Inferred from sequence orthology
  ISA Inferred from sequence alignment
  ISM Inferred from sequence model
  NAS Non-traceable author statement
  ND No biological data available
  RCA Reviewed computational analysis
  TAS Traceable author statement


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