Automated description from the Alliance of Genome Resources (Release 7.0.0)
Enables chromatin binding activity; nuclear receptor activity; and sequence-specific DNA binding activity. Involved in cellular response to estradiol stimulus and stem cell differentiation. Acts upstream of or within several processes, including mammary gland development; regulation of defense response; and reproductive structure development. Located in cytoplasm and nucleus. Is expressed in several structures, including alimentary system; brain; genitourinary system; sensory organ; and skeleton. Human ortholog(s) of this gene implicated in several diseases, including artery disease (multiple); bone disease (multiple); breast cancer (multiple); type 2 diabetes mellitus; and vitiligo. Orthologous to human ESR1 (estrogen receptor 1).