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Gene Ontology Classifications
nuclear receptor subfamily 0, group B, member 1

Go Annotations as Summary Text (Tabular View) (GO Graph)

GO curators for mouse genes have assigned the following annotations to the gene product of Nr0b1. (This text reflects annotations as of Tuesday, May 26, 2015.) MGI curation of this mouse gene is considered complete, including annotations derived from the biomedical literature as of August 20, 2007. If you know of any additional information regarding this mouse gene please let us know. Please supply mouse gene symbol and a PubMed ID.
Summary from NCBI RefSeq

[Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a protein that contains a DNA-binding domain. The encoded protein acts as a dominant-negative regulator of transcription which is mediated by the retinoic acid receptor. This protein also functions as an anti-testis gene by acting antagonistically to Sry. Mutations in this gene result in both X-linked congenital adrenal hypoplasia and hypogonadotropic hypogonadism. [provided by RefSeq, Jul 2008]
Summary text based on GO annotations supported by experimental evidence in mouse
Summary text based on GO annotations supported by experimental evidence in other organisms
Summary text based on GO annotations supported by structural data
Summary text for additional MGI annotations
  1. Babu PS et al. (2002) Interaction between Dax-1 and steroidogenic factor-1 in vivo: increased adrenal responsiveness to ACTH in the absence of Dax-1. Endocrinology, 143:665-73. (PubMed:11796523)
  2. Bouma GJ et al. (2005) Gonadal sex reversal in mutant Dax1 XY mice: a failure to upregulate Sox9 in pre-Sertoli cells. Development, 132:3045-54. (PubMed:15944188)
  3. Clipsham R et al. (2004) Nr0b1 and its network partners are expressed early in murine embryos prior to steroidogenic axis organogenesis. Gene Expr Patterns, 4:3-14. (PubMed:14678822)
  4. Eckey M et al. (2003) Mixed lineage kinase 2 enhances trans-repression of Alien and nuclear receptors. Mol Cell Endocrinol, 213:71-8. (PubMed:15062575)
  5. Gagliardi A et al. (2013) A direct physical interaction between Nanog and Sox2 regulates embryonic stem cell self-renewal. EMBO J, 32:2231-47. (PubMed:23892456)
  6. Jeffs B et al. (2001) Sertoli cell-specific rescue of fertility, but not testicular pathology, in Dax1 (Ahch)-deficient male mice. Endocrinology, 142:2481-8. (PubMed:11356697)
  7. Jeffs B et al. (2001) Blockage of the rete testis and efferent ductules by ectopic sertoli and leydig cells causes infertility in dax1-deficient male mice. Endocrinology, 142:4486-95. (PubMed:11564714)
  8. Kawajiri K et al. (2003) Role of the LXXLL-Motif and Activation Function 2 Domain in Subcellular Localization of Dax-1 (Dosage-Sensitive Sex Reversal-Adrenal Hypoplasia Congenita Critical Region on the X Chromosome, Gene 1). Mol Endocrinol, 17:994-1004. (PubMed:12610109)
  9. Lalli E et al. (2000) Orphan receptor DAX-1 is a shuttling RNA binding protein associated with polyribosomes via mRNA. Mol Cell Biol, 20:4910-21. (PubMed:10848616)
  10. Meeks JJ et al. (2003) Dax1 is required for testis determination. Nat Genet, 34:32-3. (PubMed:12679814)
  11. Niakan KK et al. (2006) Novel role for the orphan nuclear receptor Dax1 in embryogenesis, different from steroidogenesis. Mol Genet Metab, 88:261-71. (PubMed:16466956)
  12. Nishiyama A et al. (2009) Uncovering early response of gene regulatory networks in ESCs by systematic induction of transcription factors. Cell Stem Cell, 5:420-33. (PubMed:19796622)
  13. Park SY et al. (2005) Nuclear receptors Sf1 and Dax1 function cooperatively to mediate somatic cell differentiation during testis development. Development, 132:2415-23. (PubMed:15829514)
  14. Song KH et al. (2004) The atypical orphan nuclear receptor DAX-1 interacts with orphan nuclear receptor Nur77 and represses its transactivation. Mol Endocrinol, 18:1929-40. (PubMed:15155786)
  15. Swain A et al. (1998) Dax1 antagonizes Sry action in mammalian sex determination. Nature, 391:761-7. (PubMed:9486644)
  16. van den Berg DL et al. (2010) An Oct4-centered protein interaction network in embryonic stem cells. Cell Stem Cell, 6:369-81. (PubMed:20362541)
  17. Wang J et al. (2006) A protein interaction network for pluripotency of embryonic stem cells. Nature, 444:364-8. (PubMed:17093407)
  18. Yu RN et al. (1998) Role of Ahch in gonadal development and gametogenesis [see comments] Nat Genet, 20:353-7. (PubMed:9843206)

Go Annotations in Tabular Form (Text View) (GO Graph)

Filter Markers by: Category  Evidence Code 


Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment
  IAS Inferred from ancestral sequence
  IBA Inferred from biological aspect of ancestor
  IBD Inferred from biological aspect of descendant
  IC Inferred by curator
  IDA Inferred from direct assay
  IEA Inferred from electronic annotation
  IGI Inferred from genetic interaction
  IKR Inferred from key residues
  IMP Inferred from mutant phenotype
  IMR Inferred from missing residues
  IPI Inferred from physical interaction
  IRD Inferred from rapid divergence
  ISS Inferred from sequence or structural similarity
  ISO Inferred from sequence orthology
  ISA Inferred from sequence alignment
  ISM Inferred from sequence model
  NAS Non-traceable author statement
  ND No biological data available
  RCA Reviewed computational analysis
  TAS Traceable author statement


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