Automated description from the Alliance of Genome Resources (Release 3.1.1)
Exhibits damaged DNA binding activity. Predicted to contribute to DNA helicase activity. Involved in several processes, including blastocyst growth; isotype switching; and mitotic G2 DNA damage checkpoint. Localizes to PML body and replication fork. Colocalizes with nuclear chromosome, telomeric region. Is expressed in genitourinary system and pituitary gland. Used to study Nijmegen breakage syndrome. Human ortholog(s) of this gene implicated in several diseases, including Nijmegen breakage syndrome; acute lymphoblastic leukemia; aplastic anemia; breast cancer; and reproductive organ cancer (multiple). Orthologous to human NBN (nibrin).