Automated description from the Alliance of Genome Resources
Exhibits damaged DNA binding activity. Predicted to contribute to DNA helicase activity. Involved in several processes, including cell population proliferation; isotype switching; and mitotic G2 DNA damage checkpoint. Localizes to the PML body and replication fork. Colocalizes with the nuclear chromosome, telomeric region. Used to study Nijmegen breakage syndrome. Human ortholog(s) of this gene implicated in several diseases, including Nijmegen breakage syndrome; aplastic anemia; breast cancer; precursor lymphoblastic lymphoma/leukemia; and reproductive organ cancer (multiple). Orthologous to human NBN (nibrin).