Go Annotations as Summary Text (Tabular View) (GO Graph)

GO curators for mouse genes have assigned the following annotations to the gene product of Abcb11. (This text reflects annotations as of Tuesday, May 21, 2013.)

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Summary from NCBI RefSeq

The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MDR/TAP subfamily. Members of the MDR/TAP subfamily are involved in multidrug resistance. The protein encoded by this gene is the major canalicular bile salt transporter in humans and mice. Mutations in the human gene cause a form of progressive familial intrahepatic cholestases which are a group of inherited disorders with severe cholestatic liver disease from early infancy. [provided by RefSeq, Jul 2008]

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Summary text based on GO annotations supported by experimental evidence in mouse

• Researchers have inferred from direct assay, that the gene product of Abcb11
  • is located in the following cellular components:
    • apical part of cell ^[2]
    • intercellular canaliculus ^[1]
    • membrane ^[3]

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Summary text based on GO annotations supported by experimental evidence in other organisms

• From comparative sequence analysis (see table for details), MGI curators have determined that the gene product of Abcb11:
  • participates in the following biological processes:
    • canalicular bile acid transport
    • transmembrane transport
  • performs the following molecular functions:
    • ATPase activity, coupled to transmembrane movement of substances
    • canalicular bile acid transmembrane transporter activity
  • is located in the following cellular components:
    • apical plasma membrane
    • Golgi membrane
    • integral to membrane

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Summary text based on GO annotations supported by structural data

• Abcb11 encodes a protein or proteins that contain the following InterPro domains: AAA+ ATPase domain, ABC transporter, conserved site, ABC transporter, integral membrane type 1, ABC transporter, transmembrane domain, ABC transporter, transmembrane domain, type 1, ABC transporter-like, indicating that the gene product:
  • participates in the following biological processes:
    • transport
  • performs the following molecular functions:
    • ATP binding
    • ATPase activity
    • nucleoside-triphosphatase activity
    • nucleotide binding

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Summary text for additional MGI annotations

• Automated translation to GO terms of SwissProt keywords that describe Abcb11 indicates that it:
  • participates in the following biological processes:
    • transport
  • performs the following molecular functions:
    • ATP binding
    • nucleotide binding

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References

1. Kikuchi S et al. (2002) Radixin deficiency causes conjugated hyperbilirubinemia with loss of Mrp2 from bile canalicular membranes. Nat Genet, 31:320-5. (PubMed:12068294)
2. Klett EL et al. (2004) A mouse model of sitosterolemia: absence of Abcg8/sterolin-2 results in failure to secrete biliary cholesterol. BMC Med, 2:5. (PubMed:15040800)
3. Shih DQ et al. (2001) Hepatocyte nuclear factor-1alpha is an essential regulator of bile acid and plasma cholesterol metabolism. Nat Genet, 27:375-82. (PubMed:11279518)

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Gene Ontology Evidence Code Abbreviations:

EXP Inferred from experiment

IC Inferred by curator

IDA Inferred from direct assay

IEA Inferred from electronic annotation

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

ISS Inferred from sequence or structural similarity

ISO Inferred from sequence orthology

ISA Inferred from sequence alignment

ISM Inferred from sequence model

NAS Non-traceable author statement

ND No biological data available

RCA Reviewed computational analysis

TAS Traceable author statement

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