Go Annotations as Summary Text (Tabular View) (GO Graph)

GO curators for mouse genes have assigned the following annotations to the gene product of Abca3. (This text reflects annotations as of Wednesday, August 14, 2013.)

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Summary from NCBI RefSeq

[Summary is not available for the mouse gene. This summary is for the human ortholog.] The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intracellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the ABC1 subfamily. Members of the ABC1 subfamily comprise the only major ABC subfamily found exclusively in multicellular eukaryotes. The full transporter encoded by this gene may be involved in development of resistance to xenobiotics and engulfment during programmed cell death. [provided by RefSeq, Jul 2008]

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Summary text based on GO annotations supported by experimental evidence in mouse

• Researchers have inferred from direct assay, that the gene product of Abca3
  • is located in the following cellular components:
    • alveolar lamellar body membrane ^[1]

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Summary text based on GO annotations supported by experimental evidence in other organisms

• From comparative sequence analysis (see table for details), MGI curators have determined that the gene product of Abca3:
  • participates in the following biological processes:
    • transport
  • is located in the following cellular components:
    • alveolar lamellar body
    • alveolar lamellar body membrane
    • plasma membrane

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Summary text based on GO annotations supported by structural data

• Abca3 encodes a protein or proteins that contain the following InterPro domains: AAA+ ATPase domain, ABC transporter A, ABCA, ABC transporter, conserved site, ABC transporter-like, ATP-binding cassette sub-family A member 3, P-loop containing nucleoside triphosphate hydrolase, indicating that the gene product:
  • participates in the following biological processes:
    • ATP catabolic process
    • metabolic process
  • performs the following molecular functions:
    • ATP binding
    • ATPase activity
    • nucleoside-triphosphatase activity
    • nucleotide binding

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Summary text for additional MGI annotations

• Automated translation to GO terms of SwissProt keywords that describe Abca3 indicates that it:
  • performs the following molecular functions:
    • ATP binding
    • nucleotide binding
  • is located in the following cellular components:
    • integral to membrane
    • membrane

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References

1. Salaun B et al. (2004) CD208/dendritic cell-lysosomal associated membrane protein is a marker of normal and transformed type II pneumocytes. Am J Pathol, 164:861-71. (PubMed:14982840)

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Gene Ontology Evidence Code Abbreviations:

EXP Inferred from experiment

IC Inferred by curator

IDA Inferred from direct assay

IEA Inferred from electronic annotation

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

ISS Inferred from sequence or structural similarity

ISO Inferred from sequence orthology

ISA Inferred from sequence alignment

ISM Inferred from sequence model

NAS Non-traceable author statement

ND No biological data available

RCA Reviewed computational analysis

TAS Traceable author statement

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