Go Annotations as Summary Text (Tabular View) (GO Graph)

GO curators for mouse genes have assigned the following annotations to the gene product of Grm7. (This text reflects annotations as of Wednesday, January 23, 2013.) MGI curation of this mouse gene is considered complete, including annotations derived from the biomedical literature as of February 13, 2008. If you know of any additional information regarding this mouse gene please let us know. Please supply mouse gene symbol and a PubMed ID.

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Summary from NCBI RefSeq

[Summary is not available for the mouse gene. This summary is for the human ortholog.] L-glutamate is the major excitatory neurotransmitter in the central nervous system, and it activates both ionotropic and metabotropic glutamate receptors. Glutamatergic neurotransmission is involved in most aspects of normal brain function and can be perturbed in many neuropathologic conditions. The metabotropic glutamate receptors are a family of G protein-coupled receptors that have been divided into three groups on the basis of sequence homology, putative signal transduction mechanisms, and pharmacologic properties. Group I includes GRM1 and GRM5, and these receptors have been shown to activate phospholipase C. Group II includes GRM2 and GRM3, while Group III includes GRM4, GRM6, GRM7 and GRM8. Group II and III receptors are linked to the inhibition of the cyclic AMP cascade but differ in their agonist selectivities. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jun 2009]

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Summary text based on GO annotations supported by experimental evidence in mouse

• Researchers have inferred from direct assay, that the gene product of Grm7
  • participates in the following biological processes:
    • calcium ion transmembrane transport ^[7]
    • synaptic transmission ^[7]
  • performs the following molecular functions:
    • calcium channel regulator activity ^[6]
    • voltage-gated calcium channel activity ^[7]
  • is located in the following cellular components:
    • presynaptic membrane ^[7]
• Researchers have inferred, based on phenotypic analysis of mouse mutants, that the gene product of Grm7
  • participates in the following biological processes:
    • adult behavior ^[2]
    • associative learning ^[1]
    • behavioral fear response ^[5]
    • conditioned taste aversion ^[5]
    • memory ^{[1, 3]}
    • multicellular organismal response to stress ^[2]
    • neurological system process ^[3]
    • short-term memory ^[4]
    • transmission of nerve impulse ^[8]

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Summary text based on GO annotations supported by experimental evidence in other organisms

• From comparative sequence analysis (see table for details), MGI curators have determined that the gene product of Grm7:
  • participates in the following biological processes:
    • adenylate cyclase-inhibiting G-protein coupled glutamate receptor signaling pathway
    • negative regulation of adenylate cyclase activity
    • negative regulation of cAMP biosynthetic process
    • negative regulation of glutamate secretion
    • sensory perception of sound
    • synaptic transmission
  • performs the following molecular functions:
    • adenylate cyclase inhibiting G-protein coupled glutamate receptor activity
    • adenylate cyclase inhibitor activity
    • calcium ion binding
    • calmodulin binding
    • glutamate binding
    • glutamate receptor activity
    • group III metabotropic glutamate receptor activity
    • PDZ domain binding
    • serine binding
  • is located in the following cellular components:
    • asymmetric synapse
    • axon
    • axon terminus
    • cell cortex
    • cell surface
    • dendrite
    • dendritic shaft
    • Golgi apparatus
    • integral to membrane
    • membrane
    • neuronal cell body
    • postsynaptic membrane
    • presynaptic active zone
    • presynaptic membrane
    • protein complex
    • rough endoplasmic reticulum
    • synapse
    • terminal button

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Summary text based on GO annotations supported by structural data

• Grm7 encodes a protein or proteins that contain the following InterPro domains: Extracellular ligand-binding receptor, GPCR, family 3, GPCR, family 3, C-terminal, GPCR, family 3, conserved site, GPCR, family 3, metabotropic glutamate receptor, GPCR, family 3, metabotropic glutamate receptor 7, GPCR, family 3, nine cysteines domain, indicating that the gene product:
  • participates in the following biological processes:
    • G-protein coupled receptor signaling pathway
  • performs the following molecular functions:
    • G-protein coupled receptor activity

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Summary text for additional MGI annotations

• Automated translation to GO terms of SwissProt keywords that describe Grm7 indicates that it:
  • participates in the following biological processes:
    • G-protein coupled receptor signaling pathway
    • response to stimulus
    • sensory perception of smell
    • signal transduction
  • performs the following molecular functions:
    • G-protein coupled receptor activity
    • signal transducer activity
  • is located in the following cellular components:
    • plasma membrane

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References

1. Callaerts-Vegh Z et al. (2006) Concomitant deficits in working memory and fear extinction are functionally dissociated from reduced anxiety in metabotropic glutamate receptor 7-deficient mice. J Neurosci, 26:6573-82. (PubMed:16775145)
2. Cryan JF et al. (2003) Antidepressant and anxiolytic-like effects in mice lacking the group III metabotropic glutamate receptor mGluR7. Eur J Neurosci, 17:2409-17. (PubMed:12814372)
3. Holscher C et al. (2005) Lack of the metabotropic glutamate receptor subtype 7 selectively modulates Theta rhythm and working memory. Learn Mem, 12:450-5. (PubMed:16204199)
4. Holscher C et al. (2004) Lack of the metabotropic glutamate receptor subtype 7 selectively impairs short-term working memory but not long-term memory. Behav Brain Res, 154:473-81. (PubMed:15313036)
5. Masugi M et al. (1999) Metabotropic glutamate receptor subtype 7 ablation causes deficit in fear response and conditioned taste aversion. J Neurosci, 19:955-63. (PubMed:9920659)
6. Perroy J et al. (2001) The C terminus of the metabotropic glutamate receptor subtypes 2 and 7 specifies the receptor signaling pathways. J Biol Chem, 276:45800-5. (PubMed:11584003)
7. Perroy J et al. (2002) PICK1 is required for the control of synaptic transmission by the metabotropic glutamate receptor 7. EMBO J, 21:2990-9. (PubMed:12065412)
8. Sansig G et al. (2001) Increased seizure susceptibility in mice lacking metabotropic glutamate receptor 7. J Neurosci, 21:8734-45. (PubMed:11698585)

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Gene Ontology Evidence Code Abbreviations:

EXP Inferred from experiment

IC Inferred by curator

IDA Inferred from direct assay

IEA Inferred from electronic annotation

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

ISS Inferred from sequence or structural similarity

ISO Inferred from sequence orthology

ISA Inferred from sequence alignment

ISM Inferred from sequence model

NAS Non-traceable author statement

ND No biological data available

RCA Reviewed computational analysis

TAS Traceable author statement

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