Go Annotations as Summary Text (Tabular View) (GO Graph)

GO curators for mouse genes have assigned the following annotations to the gene product of Grm6. (This text reflects annotations as of Wednesday, August 14, 2013.)

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Summary from NCBI RefSeq

[Summary is not available for the mouse gene. This summary is for the human ortholog.] L-glutamate is the major excitatory neurotransmitter in the central nervous system and activates both ionotropic and metabotropic glutamate receptors. Glutamatergic neurotransmission is involved in most aspects of normal brain function and can be perturbed in many neuropathologic conditions. The metabotropic glutamate receptors are a family of G protein-coupled receptors, that have been divided into 3 groups on the basis of sequence homology, putative signal transduction mechanisms, and pharmacologic properties. Group I includes GRM1 and GRM5 and these receptors have been shown to activate phospholipase C. Group II includes GRM2 and GRM3 while Group III includes GRM4, GRM6, GRM7 and GRM8. Group II and III receptors are linked to the inhibition of the cyclic AMP cascade but differ in their agonist selectivities. [provided by RefSeq, Feb 2012]

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Summary text based on GO annotations supported by experimental evidence in mouse

• Researchers have inferred from direct assay, that the gene product of Grm6
  • is located in the following cellular components:
    • new growing cell tip ^[1]
• Researchers have inferred, based on phenotypic analysis of mouse mutants, that the gene product of Grm6
  • participates in the following biological processes:
    • locomotory behavior ^[2]
    • retina development in camera-type eye ^[3]
    • sensory perception of light stimulus ^[2]
• Researchers have inferred, based on genetic interactions, that the gene product of Grm6
  • participates in the following biological processes:
    • signal transduction based on interactions with Trpm1 ^[1]

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Summary text based on GO annotations supported by experimental evidence in other organisms

• From comparative sequence analysis (see table for details), MGI curators have determined that the gene product of Grm6:
  • participates in the following biological processes:
    • adenylate cyclase-inhibiting G-protein coupled glutamate receptor signaling pathway
  • performs the following molecular functions:
    • adenylate cyclase inhibiting G-protein coupled glutamate receptor activity

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Summary text based on GO annotations supported by structural data

• Grm6 encodes a protein or proteins that contain the following InterPro domains: Extracellular ligand-binding receptor, GPCR, family 3, GPCR, family 3, C-terminal, GPCR, family 3, conserved site, GPCR, family 3, metabotropic glutamate receptor, GPCR, family 3, metabotropic glutamate receptor 6, GPCR, family 3, nine cysteines domain, indicating that the gene product:
  • participates in the following biological processes:
    • G-protein coupled receptor signaling pathway
  • performs the following molecular functions:
    • G-protein coupled receptor activity
  • is located in the following cellular components:
    • integral to membrane

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Summary text for additional MGI annotations

• Automated translation to GO terms of SwissProt keywords that describe Grm6 indicates that it:
  • participates in the following biological processes:
    • G-protein coupled receptor signaling pathway
    • response to stimulus
  • performs the following molecular functions:
    • G-protein coupled receptor activity
    • signal transducer activity
  • is located in the following cellular components:
    • integral to membrane
    • membrane
    • plasma membrane

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References

1. Koike C et al. (2010) TRPM1 is a component of the retinal ON bipolar cell transduction channel in the mGluR6 cascade. Proc Natl Acad Sci U S A, 107:332-7. (PubMed:19966281)
2. Takao M et al. (2000) Impaired behavioral suppression by light in metabotropic glutamate receptor subtype 6-deficient mice. Neuroscience, 97:779-87. (PubMed:10842024)
3. Won J et al. (2011) Mouse model resources for vision research. J Ophthalmol, 2011:391384. (PubMed:21052544)

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Gene Ontology Evidence Code Abbreviations:

EXP Inferred from experiment

IC Inferred by curator

IDA Inferred from direct assay

IEA Inferred from electronic annotation

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

ISS Inferred from sequence or structural similarity

ISO Inferred from sequence orthology

ISA Inferred from sequence alignment

ISM Inferred from sequence model

NAS Non-traceable author statement

ND No biological data available

RCA Reviewed computational analysis

TAS Traceable author statement

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