Automated description from the Alliance of Genome Resources (Release 7.0.0)
Enables G protein-coupled receptor activity involved in regulation of postsynaptic membrane potential and neurotransmitter receptor activity involved in regulation of postsynaptic cytosolic calcium ion concentration. Involved in several processes, including calcium-mediated signaling using intracellular calcium source; cellular response to amyloid-beta; and learning or memory. Acts upstream of or within learning; locomotory behavior; and regulation of long-term neuronal synaptic plasticity. Located in cytoplasm; neuron projection; and plasma membrane. Is active in Schaffer collateral - CA1 synapse. Is expressed in central nervous system and retina. Used to study schizophrenia. Orthologous to human GRM5 (glutamate metabotropic receptor 5).